Abstract：Objective: To explore the clinical efficacy and the effect of the injection of baotase combined with ginkgo biloba in patients with sudden deafness. Methods: A total of 143 patients with sudden deafness were randomly divided into control group (n = 71) and treatment group (n = 72). Both groups of patients were treated with ginkgo biloba injection. The treatment group was based on the basic therapy combined with the treatment of balthase, continuous treatment for 2 weeks. After treatment, 2 groups of clinical efficacy were calculated. To detect and compare the changes of the pure acoustic threshold and coagulation function of the two groups before and after treatment. The adverse reactions during the treatment of 2 groups were calculated. Results: The total effective rate of treatment group was 90.28%, significantly higher than 71.83% in the control group (P<0.01). Compared with the treatment before treatment, the pure acoustic threshold of the two groups was significantly reduced after treatment. The treatment group was significantly lower than the control group (P<0.01); After treatment, both PT and APTT were significantly shortened after treatment (P <0.05 or P<0.01). The treatment group was significantly shorter than the control group (P < 0.01); The serum FIB levels were significantly lower in the 2 groups after treatment, and the treatment group was significantly lower than the control group (P<0.01). The serum d-d levels were significantly higher in 2 groups (P <0.05 or P< 0.01), and the treatment group was significantly higher than the control group (P<0.01). The incidence of adverse reactions in the treatment group was 5.56%, which was significantly lower than that in the control group (P < 0.05). Conclusion: The combination of Batroxobin and ginkgo leaf injection can effectively improve hearing and coagulation function in patients with sudden deafness, and reduce the related adverse reactions effectively. The curative effect is significantly better than that of ginkgo leaf injection.
张学红, 梁小微, 王鸿梅, 陆鸿略, 张宇丽. 巴曲酶联合银杏叶注射液治疗突发性耳聋的疗效及对患者凝血功能的影响[J]. 河北医学, 2018, 24(6): 979-982.
ZHANG Xuehong, LIANG Xiaowei, WANG Hongmei, et al. Effect and of Batroxobin Combined with Ginkgo Biloba Injection on Sudden Deafness and Influence on Coagulation Function. HeBei Med, 2018, 24(6): 979-982.
2018, Vol. 24 
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