Abstract：Objective: To investigate the effect of the combination of IL-17 and IL-35 in the treatment of chronic periodontitis and the expression of serum and gingival crevicular fluid. Methods: 130 patients of chronic periodontitis received therapy from Jan 2014 to Dec 2016 in our hospital were selected as the research object. All the patients were randomly divided into observation group and control group, each group of 65 cases. The control group was given tinidazole treatment, the observation group was treated with periocline ointment on this basis. After 4 weeks of treatment, the clinical efficacy, gingival index (GI), plaque index (PLI), periodontal attachment (PAL), periodontal pocket depth (PPD), tooth mobility (MD), Interleukin-17 (IL-17), interleukin-35 (IL-35) and adverse reactions were compared. Results: After treatment, the observation group, the total effective rate was higher than the control group (92.31% vs 73.85%, P<0.05); The GI, PLI, PAL, PPD and MD in the observation group were significantly lower than those in the control group(P<0.05); The levels of IL-17 and IL-35 in gingival crevicular fluid in observation group were lower than those in control group(351.64±41.73 vs 394.35±46.17, 100.44±7.19 vs 143.25±9.64, P<0.05); The levels of IL-17 and IL-35 in the observation group were lower than those in the control groupf[(16.05±1.07)vs(20.64±1.83)ng/L,(100.44±7.19) vs (258.17±16.94)ng/ml](P<0.05); The total incidence of adverse reactions in the observation group was lower than that in the control group (6.15% vs 18.46%, P<0.05). Conclusion: It can effectively relieve the clinical symptoms, improve the expression of IL-17 and IL-35 in gingival crevicular fluid, improve the immune function of the body, and have less adverse reactions. It is worth popularizing.
郑富军, 马芬, 田小龙. 派丽奥软膏联合替硝唑治疗慢性牙周炎的疗效及对血清与龈沟液IL-17 IL-35表达的影响[J]. 河北医学, 2018, 24(6): 1017-1020.
ZHENG Fujun, MA Fen, TIAN Xiaolong. Effect of the Treatment of Chronic Periodontitis and Expressionl of IL-17 and IL-35 in Serum and Gingival Crevicular Fluid. HeBei Med, 2018, 24(6): 1017-1020.
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2018, Vol. 24 
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