Abstract：Objective: To investigate the effect of combined use of sodium valproate and lamotrigine on peripheral blood levels of TNF and IL in patients with primary epilepsy and its efficacy and safety. Methods: The observation cases were 150 patients diagnosed as primary epilepsy in our hospital from March 2014 to March 2017. All the patients in the study were randomly divided into control group And observation group, with 75 cases in each group. The two groups were administered with valproate sodium alone and valproate combined with lamotrigine, and were followed up. The time of electroencephalogram (EEG) improvement, the proportion of abnormal discharge, the frequency of postoperative seizure, the score of SES, the levels of TNF-α and IL-2 in peripheral blood and the adverse reactions were compared between the two groups. Results: In terms of curative effect, the results of EEG improvement time and abnormal discharge proportion in the observation group were significantly lower than those in the control group (P <0.05; the frequency of seizures in the observation group at 3 months and 6 months was significantly less than that in the control group (P <0.05 =; The mean score of SES self-esteem in observation group was significantly higher than that in control group (P <0.05); the level of TNF-α and IL-2 in peripheral blood of the combination group was significantly lower than that of the control group (P <0.05) The incidence of adverse reactions in the observation group was significantly lower than the control group, higher safety. Conclusion: Sodium valproate in combination with lamotrigine has a good and stable efficacy in the treatment of epilepsy, in reducing blood levels of TNF-α and IL- 2 levels at the same time, the safety of its use is higher, the incidence of adverse reactions was significantly reduced.This method is effective and safe, it is worth promoting.
庄俊鸿, 云天, 王年臻, 周治平. 丙戊酸钠与拉莫三嗪联用对原发性癫痫患者外周血TNF-α IL-2的影响研究[J]. 河北医学, 2018, 24(6): 1007-1012.
ZHUANG Junhong, YUN Tian, WANG Nianzhen, et al. Effect of Valproate Combined with Lamotrigine on TNF- and IL-2 in Peripheral Blood of Patients with Primary Epilepsy. HeBei Med, 2018, 24(6): 1007-1012.
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2018, Vol. 24 
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