Abstract：Objective: To explore the guiding role of CT perfusion imaging in the safety and efficacy of intravenous thrombolytic therapy for acute ischemic stroke. Methods: 75 patients with acute middle cerebral artery ischemic stroke (6h) admitted in our hospital from October 2016 to December 2017 were selected as the subjects. The CBF ratio of 35 cases underwent CTP examination ranged from 0.20 to 0.35, suggesting reversible ischemia penumbra. The remaining 40 cases were examined by CTP without ischemic penumbra. The two groups were treated with rt-PA thrombolytic therapy. The bleeding conversion rate, mortality rate, NIHSS score and Barthel index score of 24h, 7d, 30d and 90d after thrombolysis in two groups were compared. Results: There were 1 case of hemorrhage conversion within 48 hours after thrombolytic therapy in IP group and 4 cases of hemorrhage conversion within 48 hours after thrombolytic therapy in no IP group,there were significant differences (P<0.05).There were no deaths in IP group after thrombolytic therapy, and there were 1 deaths in 14d after thrombolytic therapy in group IP, no significant difference (P=0.095).NIHSS scores and Barthel index scores after 24h, 7d, 30d and 90d after treatment in CTP group were better to control group and the difference was statistically significant (P<0.05). Conclusion: In the thrombolytic therapy of patients with acute ischemic stroke, according to the results of CTP examination, it is important to predict the risk of secondary hemorrhage after thrombolytic therapy, which is of great significance to the improvement and prognosis of neural function defects.
李卫来, 李琳, 李岩, 郭晓玲. CT灌注成像对急性缺血性脑卒中静脉溶栓治疗的安全性和有效性评价[J]. 河北医学, 2018, 24(6): 1004-1006.
LI Weilai, LI Lin, LI Yan, et al. Evaluation of Safety and Efficacy of CT Perfusion Imaging in Intravenous Thrombolytic Therapy for Acute Ischemic Stroke. HeBei Med, 2018, 24(6): 1004-1006.
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2018, Vol. 24 
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