Abstract：Objective: To investigate the correlation of the levels of vitamin D with oxidative stress in type 2 diabetes. Methods:107 cases of patients with type 2 diabetes hospitalized in affiliated hospital of chengde medical university were enrolled as objects of the study, the levels of vitamin D、MDA and SOD in the blood were detected. Results: The levels of vitamin D and SOD of contral group, microalbuminuria group and clinical proteinuria group were decreased,while the levels of MDA were on the rise, the differences were statistically significant(P<0.05)。 The levels of vitamin D and MDA were negtively correlated,and the levels of vitamin D and SOD were positively correlated. Conclusion:The levels of vitamin D and oxidative stress in type 2 diabetic nephropathy were negtively correlated.
何建秋, 于志伟, 李强, 高宇, 韩桂艳, 陈娇月, 勾建强. 2型糖尿病肾病患者血清维生素D水平与氧化应激的相关性研究[J]. 河北医学, 2018, 24(6): 1001-1003.
HE Jianqiu, et al. Correlation Study of the Levels of Vitamin D with Oxidative Stress in Type 2 Diabetes. HeBei Med, 2018, 24(6): 1001-1003.
[1] Plum L A,J B Zella, Vitamin D compounds and diabetic nephropathy[J].Arch Biochem Biophys,2012,523(1):87~94. [2] N. Binkley, D. Gemar, J. Engelke, et al. Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly in older adults[J].Clin Endocrinol Metab,2011,96(4):981~988. [3] Kevin A. Fiscella, Paul C. et al. Vitamin D and Racial Disparity in Albuminuria[J].Am Hypertens,2011,24(10):1114~1120. [4] Kim MJ, Frankel AH, Donaldson M, et al. Oral cholecalciferol decreases albuminuria and urinary TGF- beta1 in patients with type 2 diabetic nephropathy on established renin- angiotensin - aldosterone system inhibition[J].Kidney Int,2011,80(8):851~ 860. [5] Sonneveld R, Ferrè S, Hoenderop JG, et al. Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease[J].Am Pathol,2013,182(4):1196~1204. [6] Youli Wang, Dilip K. Deb, Zhongyi Zhang, et al. Vitamin D receptor signaling in podocytes protects against diabetic nephropathy[J].Am Soc Nephrol,2012,23(12):1977~1986. [7] 汤沂,刘晶,谢亮,等.维生素D缺乏对小鼠心肌氧化应激水平的影响及机制研究[J].医学研究生学报,2016,29(10):1050~1054. [8] Deng, X, J. Cheng, M. Shen, et al. Vitamin D improves diabetic nephropathy in rats by inhibiting renin and relieving oxidative stress[J].Endocrinol Invest,2016,39(6):657~666.
2018, Vol. 24 
冀公网安备13080202000677号