氨溴索联合雷诺考特鼻喷雾剂对分泌性中耳炎患者血清与耳积液HA sIL-2R Fn 炎性介质的影响

doi:10.3969/j.issn.1006-6233.2018.05.021

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摘要 目的:探讨氨溴索联合雷诺考特鼻喷雾剂对分泌性中耳炎患者血清与耳积液透明质酸(HA)、可溶性白介素-2受体(sIL-2R)、纤维连接蛋(Fn)、炎性介质的影响。方法:86例分泌性中耳炎患者来自于我院2013年5月至2016年11月,按抽签法分为对照组和研究组,每组43例。对照组采用基础治疗,研究组基于对照组加以氨溴索联合雷诺考特鼻喷雾剂治疗。观察并比较两组临床疗效,血清及耳积液HA,sIL-2R,Fn,白细胞介素-1β(IL-1β),白细胞介素-8(IL-8),肿瘤坏死因子-α(TNF-α),降钙素原(PCT),及不良反应发生情况。结果:研究组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清及中耳积液HA,sIL-2R,IL-1β,IL-8,TNF-α,PCT均明显下降,研究组显著低于对照组,两组Fn显著上升,研究组明显高于对照组,差异均有统计学意义(P<0.05)。两组总不良反应发生率比较无统计学意义(P>0.05)。结论:氨溴索联合雷诺考特鼻喷雾剂对分泌性中耳炎的效果确切,能够降低血清及耳积液HA、sIL-2R及炎性介质,提高Fn水平。

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关键词 ：分泌性中耳炎, 氨溴索, 雷诺考特鼻喷雾剂

Abstract：Objective: To research Influence of ambroxol joint Reynolds nasal spray on serum and middle ear effusion on hyaluronic acid (HA), Soluble interleukin-2 receptor (sIL-2 R), fibronectin (Fn) and inflammatory media in the treatment secretory otitis media. Methods: 86 cases of secretory otitis media was from May 2013 to November 2016, according to lottery method was divided into control group and research group, 43 cases in each group. The control group was treated with the basic treatment, and the research group was treated with ambroxol joint Reynolds nasal spray based on control group. Clinical curative effect, serum HA and middle ear effusion, sIL-2 R, Fn, interleukin 1β (IL-1β), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), and adverse reactions occur between two group were observed and compared. Results: Total effective rate of the research group was significantly higher than the control group, and the difference was statistically significant (P<0.05). After treatment, two groups of serum and middle ear effusion HA, sIL-2 R, IL-1β, IL-8, TNF-α, PCT was significantly lower than befroe treatment, research group was significantly lower than the control group, Fn of two group was significantly higher than control group, the control group was significantly higher than the control group, the differences were statistically significant (P<0.05). The total adverse effects rate of two group was not statistically significant (P>0.05). Conclusion: Effect is sure of ambroxol joint Reynolds nasal spray in the treatment secretory otitis media,wich can reduce serum and middle ear effusion HA, sIL-2R and inflammatory mediators, improve the level of Fn.

Key words： Secretory otitis media Ambroxol Reynolds nasal spray

基金资助:陕西省科技研究发展计划资助项目,(编号:2011K12-65)

通讯作者: 武杰

引用本文:

严斌, 吴文文, 刘博, 王博, 武杰. 氨溴索联合雷诺考特鼻喷雾剂对分泌性中耳炎患者血清与耳积液HA sIL-2R Fn 炎性介质的影响[J]. 河北医学, 2018, 24(5): 782-785.
YAN Bin, WU Wenwen, LIU Bo, et al. Influence of Ambroxol joint Reynolds Nasal Spray on Serum and Middle Ear Effusion on HA,sIL-2R, Fn and Inflammatory Media in the Treatment Secretory Otitis Media. HeBei Med, 2018, 24(5): 782-785.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.05.021 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I5/782

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