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河北医学  2018, Vol. 24 Issue (5): 711-713    DOI: 10.3969/j.issn.1006-6233.2018.05.002
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老年初诊2型糖尿病患者甲状腺功能与25-羟维生素D的相关性初探
杨瑞华
北京市第一中西医结合医院内科, 北京 朝阳区 100026
Relationship between Thyroid Function and 25- Hydroxyvitamin D in Newly Diagnosed Elderly Patients with Type 2 Diabetes Mellitus
YANG Ruihua
First Chinese and Western Medicine Combined Hospital in Beijing, Beijing Chaoyang District 100026, China
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摘要 目的:初步研究老年2型糖尿病初诊患者中25-羟维生素D水平与甲状腺功能的相关关系。方法:选择2016年2月到2017年2月在本院初诊断的老年2型糖尿病患者90例,根据25-羟维生素D[25(OH)D]的水平分为维生素D严重缺乏组、缺乏组、不足组以及正常组,比较病人血清中维生素D水平与甲状腺功能的相关性。结果:在老年2型糖尿病初诊患者中,随着25-羟维生素D含量的降低,促甲状腺激素(thyroid hormone, TSH)、糖化血红蛋白(glycosylate hemoglomin HbA1c)水平逐渐增加,组间差异具有统计学意义(P<0.05)。多元线性回归分析显示甲状旁腺激素(parathyroid hormone, PTH)、血钙(Calcium, Ca)与25(OH) D水平正相关,HbA1c、TSH以及年龄与血清中的25-羟维生素D呈明显的负相关(P<0.05)。结论:老年初诊2型糖尿病患者25-羟维生素D缺乏的影响因素可能有HbA1c、TSH以及年龄。
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杨瑞华
关键词 2型糖尿病25-羟维生素D甲状腺功能指标    
AbstractObjective: To investigate the relationship between thyroid function and 25-hydroxyvitamin D in newly diagnosed type 2 diabetes patients. Methods: Totally 90 patients with newly diagnosed type 2 diabetes treated in our hospital from February 2016 to February 2017. were divided into normal group [25 (OH) D≥30ng/ml] [30ng/mL≤25 (OH) D<30ng/mL], deficient group 10ng/mL≤5 (OH) D<20ng/mL and serious deficient group <10ng/mL, compared with the serum levels of vitamin D and thyroid function correlation. Results: The levels of thyroid stimulating hormone (TSH) and glycosylate hemoglomin (HbA1c) increased gradually with the decrease of 25-hydroxyvitamin D in the newly diagnosed patients with elderly type 2 diabetes. The difference between the four groups was statistically significant (P <0.05). Multivariate linear regression analysis showed that PTH and calcium were positively correlated with 25 (OH) D levels, whereas HbA1c, TSH, and age and 25-hydroxyvitamin D in serum were significantly negative Related (P <0.05). Conclusions: HbA1c, TSH, and age are influence 5 of 25-OH(D) deficiency in newly diagnosed type 2 diabetic patients.
Key words2 diabetes mellitus    25-hydroxyvitamin D    Thyroid function index
    
引用本文:   
杨瑞华. 老年初诊2型糖尿病患者甲状腺功能与25-羟维生素D的相关性初探[J]. 河北医学, 2018, 24(5): 711-713.
YANG Ruihua. Relationship between Thyroid Function and 25- Hydroxyvitamin D in Newly Diagnosed Elderly Patients with Type 2 Diabetes Mellitus. HeBei Med, 2018, 24(5): 711-713.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.05.002     或     http://www.hbyxzzs.cn/CN/Y2018/V24/I5/711
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