Abstract：Objective: To study the anesthetic effect of sevoflurane in the treatment of radical procedure for lung cancer and its effects on the serum E-selectin, Soluble interleukin 2 receptor(sIL-2R), β-endorphin(β-EP) and high mobility group box protein B1(HMGB1) levels. Methods: 96 cases of lung cancer patients undergoing radical procedure who were treated from March 2015 to March 2017 in our hospital were selected as research objects. According to random number table, those patients were divided into the group A (n=48) and the group B(n=48). During the operation, group A was given 1~2% sevoflurane to maintain anesthesia, group B was given 1~1.5% isoflurane to maintain anesthesia. The condition of perioperative period, the changes of serum E-selectin, sIL-2R, beta -EP and HMGB1 levels at T0 (before operation), T1 (operation; start 1h), T2 (the end of the operation) and T3 (after the operation 1h), the incidence of postoperative restlessness and adverse reactions were compared between two groups. Results: There was no significant difference in the intraoperative blood loss, intraoperative infusion volume and operation time between the two groups (P>0.05), the recovery time, extubation time, spontaneous breathing recovery time and length of stay of group A were significantly shorter than those of group B (P<0.05); the levels of serum E-selectin, sIL-2R, β-EP and HMGB1 in both groups at T1, T2 and T3 points were significantly higher than those at T0 (P<0.05); the serum levels of E-selectin, sIL-2R, β-EP and HMGB1 of group A were significantly lower than those of group B at T1, T2 and T3 points (P<0.05); the incidence of postoperative restlessness in group A was significantly lower than those in group B (P<0.05); the incidence of postoperative adverse reactions in group A was significantly lower than that in group B (P<0.05). Conclusion: Sevofluran is well for patients with radical procedure for lung cancer, which can decrease the levels of serum E-selectin, sIL-2R, β-EP and HMGB1, reduce the postoperative restlessness and adverse reaction, and promote postoperative recovery.
王高, 杨智勇, 周裕凯, 王焱, 朱勤. 七氟醚在肺癌根治术中的应用效果及对血清E-selectin sIL-2R β-EP HMGB1的影响[J]. 河北医学, 2018, 24(4): 567-570.
WANG Gao, et al. The Effect of Sevoflurane in Radical Resection of Lung Cancer and its Effect on Serum E-selectin sIL-2R beta -EP and HMGB1. HeBei Med, 2018, 24(4): 567-570.
2018, Vol. 24 
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