Abstract：Objective: To investigate the expression and clinical significance of integrin α2β1 protein and CD44V3 protein in cervical squamous cell carcinoma. Methods: Expression protein of integrinα2β1 and CD44V3 were detected in 80 cases of cervicals quamous cell carcinoma and normal cervical tissues 50 cases by SP method of immunohistochemistry. The correlation between the expression of two indexes in cervical squamous cell carcinoma and the relationship with the biological behavior of cervical squamous cell carcinoma were investigated. Result: The positive expression rates of integrin alpha 2 beta 1 protein and CD44V3 protein in cervical squamous cell carcinoma were 73.4% and 71.3%, respectively, which were all higher than those in normal cervical mucosa tissues, and the difference was statistically significant (P < 0.05). Integrin alpha 2 beta 1 protein and CD44V3 protein were significantly related to the degree of differentiation, clinical stage, lymph node metastasis and depth of invasion of cervical squamous cell carcinoma. The expression of integrin alpha 2 beta 1 protein and CD44V3 protein in the squamous cell carcinoma of the cervix was positively correlated (R =0.67). Conclusion: Expression of integrinα2β1 and CD44V3 protein may play an important role in the occurrence and development of cervical squamous cell carcinoma. They have positive synergy, and be used as a judgment of local invasion, distant metastasis and prognosis prediction factors of cervical squamous cell carcinoma.
[1] 李春梅.宫颈癌发病机制及治疗的研究进展[J].基层医学论坛,2012,16(10):1323~1325. [2] Langsenlehner U, Renner W, Wascher TC,et al.Integrin Alpha-2 and beta-3 gene ploy-morphisms and breast cancer risk[J].Breast cancer Res Treat, 2006, 97(1): 67~72. [3] Ren J,Xu S,Guo D,et al. Increased expression of α5β1-integrin is a prognostic marker for patients with gastric cancer[J]. ClinTransl Oncol,2014,16(7) : 668~674. [4] Liu JF,Fong YC,Chang CS,et al. Cyclooxygenase-2 enhances α2β1integrin expression and cell migration via EPl dependent signaling path way in human chondrosareoma cells[J].Mol Cancer,2010,9(10):43~52. [5] 郭其云. 喉癌组织中KAI1和CD44v3的表达与颈淋巴结转移的研究[J].潍坊医学院学报,2015,37(3):194~196. [6] 马登殿,袁丽丽,赵以刚,等.KALL、CD44V3表达与喉癌的相关性研究[J].山东医学专科学校学报,2009,31(2):87~90. [7] 张杰,贺宇,谢朝辉.整合素α5β1、CD44V3表达与胃癌临床病理特征的关系[J].右江民族医学院学报,2014,36(4):538~539.
2018, Vol. 24 
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