Abstract：Objective: To investigate the changes of plasma brain natriuretic peptide in children with Kawasaki disease and its correlation with cardiac function. Methods: From July 2015 to July 2017 in our hospital, 39 cases of pediatric children with Kawasaki disease as the observation group, according to the disease is divided into 20 cases of acute children, 19 cases of convalescent patients; the same period in our hospital 50 cases of healthy children as a control group. The levels of plasma brain natriuretic peptide were detected in the two groups. Meanwhile, the cardiac function indexes in the observation group were also examined. The correlation between plasma brain natriuretic peptide and cardiac function was analyzed. Results: The levels of plasma brain natriuretic peptide in acute stage were significantly higher than those in recovery stage and control group (P <0.05). The level of plasma natriuretic peptide in convalescent group was higher than that in control group, the difference was statistically significant (P <0.05).The indexes of LVSF, CI, LVEF in acute stage were significantly lower than those in recovery stage, the difference was statistically significant (P <0.05). The difference of E / A index and recovery period There was no significant difference between the two groups (P> 0.05). Sodium levels of plasma brain natriuretic peptide and children with acute LVSF, CI, LVEF indicators show a significant negative correlation (P <0.05), and E/A showed no significant correlation (P> 0.05). Conclusion: The level of plasma brain natriuretic peptide in children with acute Kawasaki disease is significantly increased, which is negatively correlated with LVSF, CI and LVEF, which is of great importance for early clinical diagnosis in children.
石正英, 管建宏, 胡静. 血浆脑利钠肽在小儿川崎病中的变化及其与心功能的相关性分析[J]. 河北医学, 2018, 24(3): 430-433.
SHI Zhengying, GUAN Jianhong, et al. Analysis of the Changes of Plasma Brain Natriuretic Peptide in children with Kawasaki Disease and its Correlation with Heart Function. HeBei Med, 2018, 24(3): 430-433.
[1] 武万良,蒋宁,史延,等.N端脑利钠肽前体在川崎病急性期的变化及临床价值[J].中国小儿急救医学,2016,23(08):561~564. [2] 薛超超,潘国权,仇慧仙,等.不同血压类型川崎病患儿的临床特点分析[J].医学研究杂志,2017,46(04):78~82. [3] 王祥,陈智,肖云彬,等.血N末端脑利钠肽原和降钙素原在川崎病诊断中的价值[J].中国中西医结合儿科学,2017,9(04):301~303. [4] 王金菊,陈宗波,王文棣.川崎病患儿心型脂肪酸结合蛋白和脑利钠肽的变化及与心功能的关系[J].中国小儿急救医学,2015,22(04):273~275. [5] Huiling L, Yaping L, Xiufen H.Prediction of the risk of coronary arterial lesions in Kawasaki disease by N-terminal pro-brain natriuretic peptide[J].Zhonghua Er Ke Za Zhi,2015,53(4):300~303. [6] 王晓旭,王晓楠,王文超,等.川崎病患儿血清脑利钠肽、心型脂肪酸结合蛋白的变化及其与心功能的关系[J].中华实用儿科临床杂志,2017,32(9):705~707. [7] 方炳武,黄俊长,林俊芳.血清Nt－proBNP在小儿川崎病中的浓度变化研究及临床意义[J].吉林医学,2016,37(09):2192~2194. [8] Hashimoto I, Watanabe K, Okabe M,et al.Impairment of left ventricular longitudinal contraction is associated with serum brain natriuretic peptide concentration in patients with acute-phase kawasaki disease[J].Pediatr Cardiol,2015,36(5):979~986. [9] Adjagba P M, Desjardins L, Fournier A,et al.N-terminal pro-brain natriuretic peptide in acute Kawasaki disease correlates with coronary artery involvement[J].Cardiol Young,2015,25(7):1311~1318. [10] 邓懋恩,杨银广,黄祯,等.小儿川崎病冠脉病变临床诊断中超声心动图的应用价值研究[J].中国医学创新,2017,14(09):74~76. [11] Wu L, Chen Y, Zhong S,et al.Blood N-terminal pro-brain natriuretic peptide and interleukin-17 for distinguishing incomplete kawasaki disease from infectious diseases[J].Indian Pediatr,2015,52(6):477~480. [12] 丁会玲,裴红莲,李春丽,等.血浆氨基末端脑钠尿肽原与川崎病的相关性研究[J].中国妇幼保健,2016,31(14):2902~2905.
2018, Vol. 24 
冀公网安备13080202000677号