HIF-1α Glut-1表达与乳腺癌分化程度及分子亚型的关系

doi:10.3969/j.issn.1006-6233.2018.03.001

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摘要 目的: 探讨缺氧诱导因素-1α(HIF-1α)、葡萄糖转运蛋白1(Glut-1)表达与乳腺癌分化程度及分子亚型的关系。方法: 采用免疫组化方法检测102例乳腺癌及60例癌旁正常组织的中HIF-1α、Glut-1蛋白表达情况,比较不同分化程度、分子分型乳腺癌组织中HIF-1α、Glut-1阳性表达率。结果: 乳腺癌组织中HIF-1α、Glut-1蛋白阳性表达率分别为62.75%、68.63%高于癌旁正常组织的11.67%、16.67%,差异有统计学意义(P<0.05);高分化乳腺癌组织HIF-1α、Glut-1蛋白阳性表达率分别为34.78%、40.91%低于中分化的60.0%、68.88%和低分化的85.29%、88.24%(P<0.025),中分化低于低分化,差异有统计学意义(P<0.025);Luminal A型HIF-1α、Glut-1蛋白阳性表达率分别为46.67%、51.11%,与Luminal B型的54.55%、63.64%比较,差异无统计学意义(P>0.017),但Luminal A型、Luminal B型均低于HER-2过表达型的85.71%、92.86%和三阴型的90.48%、95.24%,差异有统计学意义(P<0.017),HER-2过表达型、三阴型比较,差异无统计学意义(P>0.017)。结论: 乳腺癌患者HIF-1α、Glut-1呈高阳性表达,且不同分化程度、分子亚型的乳腺癌HIF-1α、Glut-1阳性表达存在差异。

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关键词 ：缺氧诱导因素-1α, 葡萄糖转运蛋白1, 乳腺癌, 分子分级, 分化程度

Abstract：Objective: To investigate the relationship between the expression of -1 - alpha (HIF-1-α), glucose transporter 1 (Glut-1) and the degree of differentiation and molecular subtypes of breast cancer. Methods: Immunohistochemical method was used to detect the expression of HIF-1α and Glut-1 in 102 cases of breast cancer and 60 cases of adjacent normal tissues. The expression rates of HIF-1α and Glut-1 in breast cancer tissues with different degree of differentiation and molecular typing were compared. Results: The positive expression rates of HIF-1α and Glut-1 protein in breast cancer tissues were 62.75% and 68.63%, respectively, which were higher than those in 11.67% normal tissues. The difference was statistically significant (P < 0.05). The positive expression rates of HIF-1α and Glut-1 protein in high differentiated breast cancer tissues were 34.78% and 40.91%, respectively, which were lower than those of moderately differentiated 60%, 68.88%, and poorly differentiated 85.29% and 88.24% (P < 0.025). The differentiation of moderately differentiated breast cancer was lower than that of poorly differentiated ones (P < 0.025). There was no significant difference in positive expression rates of HIF-1α and Glut-1 protein between Luminal A type breast caner and Luminal B type breast caner (46.67% and 51.11% vs 54.55% and 63.64%) (P > 0.017). However, the rates in Luminal A and Luminal B type breast cancer were all lower than those in tissues with over-expressed HER-2 (85.71%, 92.86%) and triple negative breast cancer (90.48% and 95.24%) (P < 0.017). There was no significant difference between HER-2 overexpression type and three yin type (P > 0.017). Conclusion: The expression of HIF-1α and Glut-1 in breast cancer patients is highly positive, and the positive expression of HIF-1 alpha and Glut-1 in different degree of differentiation and molecular subtype of breast cancer is different.

Key words： Hypoxia inducible factor-1α Glucose transporter 1 Breast cancer Molecular classification Differentiation degree

基金资助:河北省保定市科学研究与发展计划项目,(编号:16ZF110)

通讯作者: 张金库

引用本文:

赵文明, 周炳娟, 李金梅, 陈雪, 张金库. HIF-1α Glut-1表达与乳腺癌分化程度及分子亚型的关系[J]. 河北医学, 2018, 24(3): 353-357.
ZHAO Wenming, ZHOU Bingjuan, LI Jinmei, et al. The Relationship between the Expression of A and B and the Degree of Differentiation and Subtypes of Breast Cancer. HeBei Med, 2018, 24(3): 353-357.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.03.001 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I3/353

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