多囊卵巢综合征患者血清网膜素水平及其临床意义

doi:10.3969/j.issn.1006-6233.2018.02.013

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摘要 目的: 探究多囊卵巢综合征(PCOS)患者血清网膜素水平及临床意义。方法: 纳入2016年1月至2016年7月我院多囊卵巢综合征患者120例作为PCOS组,同时纳入同时期来我院体检的健康志愿者120例女性作为健康对照组,比较两组黄体生成素(luteotropic hormone,LH) 、卵泡刺激素( follicle stimulatin hormone,FSH) 、睾酮( testosterone,T) 、雌二醇(estradiol,E₂)、垂体泌乳素(pituitary prolactin,PRL)5项性激素指标和空腹胰岛素(fasting serum lisulin,FINS)、空腹血糖(fasting blood glucose,FBG)水平,并比较两组稳态模型胰岛素抵抗指数(homeostasis model assessment-insulinresistance,HOMA-IR)及血清网膜素(omentin)水平。结果: PCOS组血清LH、T水平高于健康对照组(P<0.05),而血清FSH水平要低于健康对照组(P<0.05);PCOS组患者的FINS、HOMA-IR水平均要高于健康组,差异具有统计学意义(P<0.05);PCOS组患者血清Omentin低于健康对照组,差异具有统计学意义(P<0.05);且PCOS组患者血清Omentin水平与HOMA-IR 指数呈负相关性(R2=0.798; P < 0.001)。结论: 血清Omentin的下降会导致胰岛素抵抗的上升,间接影响PCOS患者血糖水平,可作为相关实验室指标对PCOS患者进行辅助性治疗。

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	邓岳红

关键词 ：多囊卵巢综合征, 血清网膜素, 胰岛素抵抗

Abstract：Objective: To investigate the serum level of serum retinin and its clinical significance in patients with polycystic ovary syndrome (PCOS). Methods: 120 patients with PCOS admitted to our hospital from January 2016 to July 2016 were enrolled as PCOS group and 120 healthy volunteers were enrolled in this study as healthy control group. Meanwhile, Luteotropic hormone (LH), follicle stimulatin hormone (FSH), testosterone (T), estradiol (E2) and pituitary prolactin (PRL) Fasting serum insulin (FINS) and fasting blood glucose (FBG) were measured. The levels of homeostasis model assessment-insulin resistance (HOMA-IR) and serum retinal omentin. Results: The levels of serum LH and T in PCOS group were significantly higher than those in healthy control group (P <0.05), while the levels of serum FSH in PCOS group were significantly lower than those in healthy control group (P <0.05). The levels of FINS and HOMA-IR in PCOS group were higher (P <0.05). The level of serum Omentin in patients with PCOS was lower than that in healthy controls (P <0.05). The level of serum Omentin was negatively correlated with HOMA-IR index in patients with PCOS (R2 = 0.798; P <0.001) . Conclusions: The decline of serum Omentin will lead to the rise of insulin resistance and indirectly affect the blood glucose level of PCOS patients. It may be used as an adjunctive therapy for PCOS patients as the relevant laboratory index.

Key words： Polycystic ovary syndrome Serum omentum Insulin resistance

引用本文:

邓岳红. 多囊卵巢综合征患者血清网膜素水平及其临床意义[J]. 河北医学, 2018, 24(2): 232-235.
DENG Yuehong. Serum OPG in Patients with Polycystic Ovary Syndrome and its Clinical Significance. HeBei Med, 2018, 24(2): 232-235.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.02.013 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I2/232