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河北医学  2018, Vol. 24 Issue (2): 228-232    DOI: 10.3969/j.issn.1006-6233.2018.02.012
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丹参川芎嗪注射液辅助治疗对顽固性高血压患者血清CRP及同型半胱氨酸水平影响研究
马建林, 王晓红, 李春梅, 陈永新, 谢德霞, 张翠芳
青海省红十字医院, 青海 西宁 810000
Study on the Effect of Salvia Miltiorrhiza Ligustrazine Injection in the Treatment of Refractory Hypertension in Elder in Serum CRP and Homocysteine
MA Jianlin, WANG Xiaohong, LI Chunmei, et al
Qinghai Red Cross Hospital, Qinghai Xining 810000, China
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摘要 目的: 探讨丹参川芎嗪注射液辅助治疗对顽固性高血压患者血清CRP及同型半胱氨酸水平影响。方法: 将在我院进行治疗的90例顽固性高血压患者进行对照探究,对照组44厄贝沙坦氢氯噻嗪进行治疗,研究组46例患者在此基础上给予丹参川芎嗪注射液进行辅助治疗,总疗程为14d。对比研究两组患者不同治疗方法后的实验室指标的变化,以探究丹参川芎嗪注射液辅助治疗对顽固性高血压疗效机制。结果: 治疗14d后两组治疗后的舒张压和收缩压都低于治疗前,差异具有统计学意义(P<0.05),而且研究组患者治疗后平均血压均低于对照组,差异具有统计学意义(P<0.05)。经过14d治疗后,研究组的总有效率高于照组,差异具有统计学意义(P<0.05)。治疗前,两组CRP、Hcy、全血高切粘度、全血低切粘度均差异无统计学意义,治疗后,研究组CRP、Hcy、全血高切粘度、全血低切粘度改善程度均优于对照组,两组差异有统计学意义。结论: 丹参川芎嗪注射液辅助治疗对顽固性高血压患者血清CRP及同型半胱氨酸水平有显著的改善作用,具有较好的临床治疗效果。
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关键词 丹参川芎嗪注射液顽固性高血压同型半胱氨酸C-反应蛋白    
AbstractObjective: To investigate the effect of Salvia miltiorrhiza Ligustrazine Injection in the treatment of Refractory hypertension in elder in serum CRP and homocysteine. Methods: 90 cases with refractory hypertension in our hospital were selected and divided into 2 groups, 44 cased in the control group received irbesartan and hydrochlorothiazide treatment, 44 cases in the treatment group received more with Salvia miltiorrhiza Ligustrazine Injection treatment, a total of 14 days treatment. Changes of laboratory indexes were compared to explore the clinical effect and mechanism of the Salvia miltiorrhiza Ligustrazine Injection in the treatment of Refractory hypertension. Results: After 14 days of treatment, diastolic blood pressure and systolic blood pressure in 2 groups were significantly decreased than before(P<0.05), and the average blood pressure in the treatment group was lower than the control group(P<0.05). After 14 days of treatment, the total effective rate of the treatment group was significantly higher than the control group(P<0.05). Before treatment, two groups of CRP, Hcy, whole blood viscosity, whole blood low shear viscosity was no significant difference after treatment, CRP, Hcy, whole blood viscosity, whole blood low shear viscosity of treatment group improvement were better than the control group, there was significant difference between two groups. (P<0.05). Conclusion: Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection adjuvant therapy can significantly improve serum CRP and homocysteine levels in patients with refractory hypertension, and it has good clinical therapeutic effect.
Key wordsSalvia miltiorrhiza Ligustrazine Injection    Resistant hypertension    Homocysteine    C-reactive protein
    
基金资助:青海省创新方法工作专项课题,(编号:2016SQ056)
引用本文:   
马建林, 王晓红, 李春梅, 陈永新, 谢德霞, 张翠芳. 丹参川芎嗪注射液辅助治疗对顽固性高血压患者血清CRP及同型半胱氨酸水平影响研究[J]. 河北医学, 2018, 24(2): 228-232.
MA Jianlin, WANG Xiaohong, LI Chunmei, et al. Study on the Effect of Salvia Miltiorrhiza Ligustrazine Injection in the Treatment of Refractory Hypertension in Elder in Serum CRP and Homocysteine. HeBei Med, 2018, 24(2): 228-232.
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