阿司匹林治疗原发性高血压合并冠心病的有效性及其对血浆黏度及血小板聚集率的影响

doi:10.3969/j.issn.1006-6233.2018.02.008

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摘要 目的: 探讨阿司匹林治疗高血压合并冠心病有效性及其对血浆黏度、血小板聚集率的影响。方法: 将107例高血压合并冠心病患者采用随机数字表法随机分为研究组(56例)和对照组(51例)。对照组给予替米沙坦(40mg/d)、硝酸异山梨酯片(30mg/次,3次/d)等进行治疗,研究组在对照组的基础上加用阿司匹林(100mg/d)。比较两组治疗前及治疗6个月时的血压、血脂、左室射血分数(LVEF)、血浆黏度及血小板聚集率变化。结果: 治疗6个月后,两组血压、TC、TG、血浆黏度及血小板聚集率均有不同程度的下降,且研究组血浆黏度、血小板聚集率下降更明显(P<0.05);两组LVEF均显著升高(P<0.01),且研究组LVEF水平明显高于对照组(P<0.05);研究组治疗的总有效率明显高于对照组(90.9% vs 76.5%,P<0.05)。结论: 阿司匹林能够显著改善高血压合并冠心病患者的血液黏度及LVEF水平,提高临床疗效。

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	崔琳琳
	高国杰
	胡桃红

关键词 ：替米沙坦片, 阿司匹林, 原发性高血压, 冠心病

Abstract：Objective: To observe the curative efficiency of aspirin on primary hypertension combined with coronary heart disease(CHD) and its influence on plasma viscosity and platelet aggregation rate. Methods: A total of 107 cases of primary hypertension patients with coronary heart disease were randomly divided into two groups by the random number table method: the study group (56 cases) and the control group (51 cases). The control group were given Telmisartan (40mg/d), Isosorbide Dinitrate tablets (30mg once, 3 times per day), while the study group were given aspirin (100mg/d) on the basis of the control group. Compare the blood pressure, blood lipid levels, left ventricular ejection fraction (LVEF), plasma viscosity and platelet aggregation rate changes of the two groups before and after 6 months' treatment. Results: After 6 months' treatment, the level of blood pressure, TC, TG, plasma viscosity and platelet aggregation rate of both groups were all declined on different degree, while the level of plasma viscosity and platelet aggregation rate of the study group were more significant lower than that of the control group (P<0.05). In addition, the LVEF of both groups were all increased significantly (P<0.01), and the LVEF level of the study group were significantly higher than the control group (P<0.05); the total effective rate of the study group were significantly higher than the control group (90.9% vs 76.5%, P<0.05). Conclusion: The therapy of aspirin can improve the blood viscosity and LVEF level for primary hypertension patients with CHD, and improve the curative efficiency as well.

Key words： Telmisartan tablets Aspirin Primary hypertension Coronary heart disease

基金资助:国家科技计划课题,(编号:2009BAI86B04)

通讯作者: 胡桃红

引用本文:

崔琳琳, 高国杰, 胡桃红. 阿司匹林治疗原发性高血压合并冠心病的有效性及其对血浆黏度及血小板聚集率的影响[J]. 河北医学, 2018, 24(2): 211-215.
CUI Linlin, GAO Guojie, HU Taohong. The Efficacy of Aspirin in the Treatment of Primary Hypertension with CHD and its Effect on Plasma Viscosity and Platelet Aggregation Rate. HeBei Med, 2018, 24(2): 211-215.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.02.008 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I2/211

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