Abstract：Objective: To investigate the clinical effect of blood perfusion on children with severe abdominal allergic purpura. Methods: 28 children with severe abdominal allergic purpura were enrolled in our hospital from August 2013 to March 2018. They were divided into observation group A (blood perfusion) and observation group B according to different treatment methods. Treatment), another 14 healthy children were selected as healthy control group, serum tumor necrosis factor (TNF-α), interleukin-6 (IL-6), plasma malondialdehyde (MDA), superoxide before and after treatment in three groups of children. The level of dismutase (SOD) and total plasma antioxidant capacity (T-AOC) were measured. Results: The levels of MDA, TNF-α and IL-6 in group A were significantly lower than those in group B. The levels of T-AOC and SOD were significantly higher than those in group B. The difference was significant (P<0.05). The incidence of rash and gastrointestinal symptoms disappeared significantly in group A, and the difference was significant (P<0.05). The incidence of abdominal pain/rash recurrence and renal damage during follow-up were observed in group A. Compared with the observation group B, the average daily dose of hormone was significantly lower than the latter, and the difference was significant (P<0.05). Conclusion: For children with severe abdominal allergic purpura, combined with blood perfusion on the basis of conventional treatment, can effectively improve the clearance of inflammatory mediators and oxidative stress products, and is very positive for restoring the immune mechanism and oxidation balance of the body. It is conducive to enhancing the clinical treatment effect and reducing the pain of children. It is recommended to be applied in clinical practice.
罗明海,张森山. 血液灌流治疗儿童重症腹型过敏性紫癜的临床疗效分析[J]. 河北医学, 2018, 24(12): 2054-2057.
LUO Minghai, ZHANG Senshan. Clinical Efficacy of Hemoperfusion in the Treatment of Severe Abdominal Allergic Purpura in Children. HeBei Med, 2018, 24(12): 2054-2057.
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2018, Vol. 24 
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