Abstract：Objective: To analyze the clinical effect of complete laparoscopy in the treatment of elderly patients with primary hepatocellular carcinoma and its effects on serum vascular endothelial growth factor (VEGF), transforming growth factor-alpha (TGF-alpha), soluble intercellular adhesion molecule-1 (SICAM-1). Methods: 84 patients with primary hepatocellular carcinoma according to simple random number table method were divided into 44 control group and 40 research group. control group was treated with open hepatectomy, and the research group was treated with complete laparoscopi. surgical index, serum VEGF, TGF-α, SICAM-1, liver function, complications and follow-up in both group were compared. Results: There was no significant difference in operative time between the two groups (P>0.05). 1 months and 3 months after operation, the blood loss, feeding time, getting out of bed and hospitalization time in the study group were less than those in the control group (P<0.05). Three days and seven days after operation, the liver function indexes of the two groups were higher than those before operation (P<0.05), but the change range of the study group was smaller, and there was statistical difference between the two groups (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). There was no significant difference in 1-year recurrence rate, 2-year recurrence rate, 1-year survival rate and 2-year survival rate between the two groups (P>0.05). Conclusion: Complete laparoscopic treatment of elderly patients with primary hepatocellular carcinoma can reduce serum levels of vascular endothelial growth factor, TGF-alpha and SICAM-1, achieve the same safety and survival rate as open surgery, and have more advantages in surgical trauma and liver function.
梅勇,杨旭辉,刘颜,周志林. 完全腹腔镜术治疗老年原发性肝细胞癌的临床疗效及对血清VEGF TGF-α SICAM-1的影响[J]. 河北医学, 2018, 24(12): 2032-2036.
MEI Yong, YANG Xuhui, LIU Yan, et al. Effect of Total Laparoscopy on Serum Levels of VEGF TGF-alpha and SICAM-1 in Elderly Patients with Primary Hepatocellular Carcinoma. HeBei Med, 2018, 24(12): 2032-2036.
[1] Jordan EJ, Basturk O, Shia J, et al. Case report: primary acinar cell carcinoma of the liver treated with multimodality therapy[J].Gastrointest Oncol, 2017,8(5):E65~E72. [2] 欧阳正晟,唐朝晖,吕丽娟,等.腹腔镜肝切除与开腹肝切除治疗原发性肝癌的临床比较[J].中国普通外科杂志,2017,26(1):126~130. [3] Skulimowski A, Hogendorf P, Poznańska G, et al. Successful hemihepatectomy following chemotherapy for primary liver lymphoma: case report and review of literature[J]. Pol Przegl Chir,2017,89(5):54~58. . [4] 张杰, 张耀军,陈敏山,等.完全腹腔镜下复发性肝癌切除术的疗效分析[J].中华肝胆外科杂志,2016,22(4):227~230. [5] Danoy M, Shinohara M, Rizki-Safitri A, et al. Alteration of pancreatic carcinoma and promyeloblastic cell adhesion in liver microvasculature by co-culture of hepatocytes, hepatic stellate cells and endothelial cells in a physiologically-relevant model[J]. Integr Biol (Camb), 2017,9(4):350~361. [6] 中华人民共和国卫生部.原发性肝癌诊疗规范(2011年版)摘要[J].中华肝脏病杂志,2012,20(6):929~946. [7] 李轲宇,刘连新,尹大龙.肝细胞癌外科治疗方式的研究进展[J].中华外科杂志,2016,54(2):148~152. [8] 熊勇,王何斌,刘德钦,等.完全腹腔镜与开腹肝切除术治疗左外叶肝细胞癌的效果比较[J].临床肝胆病杂志,2016,32(4):735~738. [9] 丁振昊,蒋力,张珂,等.腹腔镜与开放式肝癌切除术治疗原发性肝癌患者临床效果对比分析[J].临床和实验医学杂志,2015,14(13):1113~1116. [10] 徐畅,罗祥基,吴孟超,等.腹腔镜肝切除与开腹肝切除治疗原发性肝癌安全性及疗效的Meta分析[J].海军医学杂志,2016,37(5):439~442. [11] Denies S, Leyman B, Huysmans H, et al. Evaluation of a xenogeneic vascular endothelial growth factor-2 vaccine in two preclinical metastatic tumor models in mice[J]. Cancer Immunol Immunother,2017,66(12):1545~1555. . [12] Yu SS, Chen B, Huang CK, et al. Ursolic acid suppresses TGF-β1-induced quiescent HSC activation and transformation by inhibiting NADPH oxidase expression and Hedgehog signaling[J]. Exp Ther Med, 2017,14(4):3577~3582. [13] 伍强,李光耀,皮儒先,等.LLLR与OLLR治疗左外叶肝细胞癌临床效果及远期生存率比较[J].实用肝脏病杂志,2017,20(4):451~454. [14] 俞小炯,张浩,董科,等.完全腹腔镜和开腹肝切除手术治疗原发性肝细胞肝癌的近期和远期疗效比较[J].实用医学杂志,2017,33(12):1943~1948.
2018, Vol. 24 
冀公网安备13080202000677号