Abstract：Objective: To investigate the changes of platelet mitochondrial function in asthmatic patients. Methods: 122 cases were diagnosed as acute episode of asthma from April 2016 to May 2017. According to the severity grading standard, they were divided into 4 groups, 45 cases of intermittent state (first grade), 23 cases of mild asthma (second grade), 30 cases of moderate asthma (third grade) and 24 cases of severe asthma (fourth grade). 44 cases of normal control group came from the physical examination center at same time. Platelet and platelet mitochondria were separated from blood samples. The ultrastructure of platelets was observed by transmission electron microscopy. The platelet mitochondrial membrane potential (MMP), cytochrome C oxidase (COX) activity and adenosine triphosphate (ATP) activity were detected and their differences were analyzed. Results: There were significant differences in platelet mitochondrial membrane potential (MMP), cytochrome C oxidase (COX) activity and adenosine triphosphate (ATP) between asthma group and normal group (P<0.05). The mitochondrial function (MMP, ATP, COX) of asthmatic patients with different severity was significantly different from that of normal control group (P<0.05). Conclusion: There are mitochondrial respiratory chain inhibition and impaired function in asthmatic patients. Mitochondrial damage and dysfunction may play an important role in the pathogenesis of asthma.
刘慧芳,马红霞. 不同病情严重程度支气管哮喘患者的线粒体功能变化[J]. 河北医学, 2018, 24(11): 1765-1768.
LIU Huifang, MA Hongxia. Changes of Platelet Mitochondrial Function in Asthmatic Patients. HeBei Med, 2018, 24(11): 1765-1768.
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2018, Vol. 24 
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