Abstract：Objective: To explore rifabutin combined with antiviral drug clinical effect in the treatment of AIDS with tuberculosis. Methods: 80 AIDS patients with pulmonary tuberculosis admitted to our hospital from January 2014 to December 2015 were selected as the subjects of this study. According to the difference of clinical medication, they were divided into observation group and reference group. There were 40 cases in each group of two groups. The observation group was given the anti-tuberculosis regimen containing forbestine plus the anti-tuberculosis regimen containing efoviran or cleistogen, and the control group was given the anti-tuberculosis regimen containing rifampicin plus the anti-virus regimen containing efoviran. Both groups were given anti-tuberculosis and anti-HIV treatment. The anti-tuberculosis, anti-virus and total adverse reactions of the two groups were observed. Situation. Results: The effective rate of anti-tuberculosis treatment, negative rate of sputum examination, closure rate of pulmonary cavity and absorption of pulmonary lesions in the study group were significantly higher than those in the control group (P<0.05). There was no significant difference in the CD4+T lymphocyte between the two groups before treatment (P>0.05). After treatment, CD4 + T lymphocytes in both groups were significantly higher than those in the control group (P<0.05). The incidence of immune reconstitution inflammatory syndrome and total adverse reactions in the study group were significantly lower than those in the control group (P<0.05). Conclusion: Rifambutin combined with antiviral treatment of pulmonary tuberculosis with significant clinical effect, can effectively improve the cure rate of patients, reduce adverse reactions, reduce the incidence of immune reconstruction inflammatory syndrome, increase the anti-tuberculosis and antiviral efficacy.
何华伟,卢祥婵. 利福布汀联合抗病毒药物治疗艾滋病合并结核病的临床研究[J]. 河北医学, 2018, 24(10): 1743-1747.
HE Huawei, LU Xiangchan, HUANG Aichun, et al. Clinical Study of Rifabutin Combined with Antiviral in the Treatment of AIDS with Tuberculosis. HeBei Med, 2018, 24(10): 1743-1747.
2018, Vol. 24 
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