Abstract：Objective: To explore the early diagnostic efficacy of NT-proBNP and eGFR-CysC in patients with chronic renal failure complicated with cardiac insufficiency. Methods: A total of 147 patients with chronic renal failure diagnosed in our department from December 2015 to August 2017 were selected as the study subjects. 83 patients with cardiac insufficiency included in the study group, and the remaining 64 patients without cardiac insufficiency were treated as control group. Their baseline data, left ventricular end-diastolic diameter (LVDd), left atrial diameter (LADd), left ventricular ejection fraction (LVEF), troponin (cTnI), NT-proBNP, glomerular filtration rate (CysC) and eGFR-CysC were recorded. Univariate analysis and multivariate unconditional logistic regression were applied to select the factor that may affect chronic heart failure complicated with cardiac insufficiency. The relationship between eGFR-CysC and NT-proBNP was analyzed by Pearson analysis and ROC curve was used to show the sensitivity and specificity of above indicators in the diagnosis of patients with chronic renal failure complicated with cardiac insufficiency. Results: Univariate analysis showed that the levels of LVDd, cTnI, NT-proBNP, and CysC in patients with cardiac insufficiency were higher than those in control group; while the levels of LVEF and eGFR-CysC were lower than those in control group, and the differences were statistically significant (P<0.05); Multivariate Logistic regression analysis showed low LVEF, high NT-proBNP and Low levels of eGFR-CysC were risk factors for cardiac insufficiency in patients with renal failure. Pearson correlation analysis showed that the increase of eGFR-CysC was negatively correlated with the increase of NT-proBNP (r=-0.665, P=0.002). The AUC of eGFR-CysC under the ROC curve was the highest, with a specificity of 79.67% and a sensitivity of 82.89%. Conclusion: eGFR-CysC has a good diagnostic effect on patients with chronic renal failure complicated with cardiac insufficiency. It is expected to be used as one of the early detection indicators of cardiac insufficiency in patients with chronic renal failure.
宋家志,刘婧,王焕霞. NT-proBNP eGFR-CysC诊断CRF患者心功能不全的临床价值分析[J]. 河北医学, 2018, 24(10): 1711-1714.
SONG Jiazhi, LIU Jing, et al. Clinical Value Analysis of NT-proBNP and eGFR-CysC in Diagnosis of Cardiac Insufficiency in CRF Patients. HeBei Med, 2018, 24(10): 1711-1714.
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2018, Vol. 24 
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