Abstract：Objective:To analyze the characteristics of TG, TC, LDL-C, LDL-C/HDL-C in preeclampsia and its relationship with adverse pregnancy outcomes. Methods:A total of 98 cases of preeclampsia pregnant women were selected, the 98 cases healthy pregnant women of the hospital in the same period were randomly selected as the control group. The lipid levels of the two groups were measured, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and calculated blood lipid ratio TC/HDL-C, TG/HDL-C, LDL-C/HDL-C and were compared between the PE group and the control group. The pregnancy outcome of pregnant women with PE was observed, compare TC, TG, LDL-C, HDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C in pregnant women with adverse pregnancy outcomes and those without adverse pregnancy outcomes. And analyzed multivariate logistic regression analysis of adverse pregnancy outcomes. Results: There were no significant difference in serum TC, LDL-C and HDL-C between the two groups (P>0.05). The serum TG levels in PE group was significantly higher than that in control group (t=6.556, P<0.05). The TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C in the PE group were significantly higher than those in the control group (t=4.723, 7.996, 5.445, P<0.05). Among 98 pregnant women with PE, the overall incidence of adverse pregnancy outcomes was 24.48% (24/98). There were no significant difference in the levels of TC, LDL-C and HDL-C between pregnant women with adverse pregnancy outcomes and those without adverse pregnancy outcomes (P>0.05), while the TG、TC/HDL-C、TG/HDL-C、LDL-C/HDL-C levels were statistically significant (P<0.05). The multivariate logistic regression analysis showed that TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C were the influencing factors of adverse pregnancy outcome (P<0.05). Conclusion: The TG, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C in PE pregnant women were significantly higher than those in the control group, among which TC/HDL-C, TG/HDL-C, LDL-C/HDL-C Influencing factors for adverse pregnancy outcomes in PE pregnant women.
[1] Huang S, Mo TT, Norris T, et al. The CLIMB (Complex Lipids In Mothers and Babies) study: protocol for a multicentre, three-group, parallel randomised controlled trial to investigate the effect of supplementation of complex lipids in pregnancy, on maternal ganglioside status and subsequent cognitive outcomes in the offspring[J]. BMJ Open,2017,7(10):16637~16640. [2] 陈鹏,史琳,杨红梅,等.妊娠期高血压、子痫前期及子痫与孕前和孕期体质量及其他因素的相关性研究[J].实用妇产科杂志,2017,33(11):848~852. [3] Huai J, Yang Z, Yi YH, et al. Different effects of pravastatin on preeclampsia-like symptoms in different mouse models[J]. Chin Med,2018,131(4):461~470. [4] 丰有吉,沈铿.妇产科学[M].第8版.人民卫生出版社,2013.242~244. [5] Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, et al. Efficacy of nanocurcumin supplementation on insulin resistance, lipids, inflammatory factors and nesfatin among obese patients with non-alcoholic fatty liver disease (NAFLD): a trial protocol[J]. BMJ Open, 2017,7(7):16914~16916. [6] Kreepala C, Kitporntheranunt M, Sangwipasnapaporn W, et al. Assessment of preeclampsia risk by use of serum ionized magnesium-based equation[J]. Ren Fail,2018,40(1):99~106. [7] Erez O, Romero R, Vaisbuch E, et al. Tissue factor activity in women with preeclampsia or SGA: a potential explanation for the excessive thrombin generation in these syndromes[J].Matern Fetal Neonatal Med,2018,31(12):1568~1577. [8] Cho GJ, Kim LY, Min KJ, et al. Prior cesarean section is associated with increased preeclampsia risk in a subsequent pregnancy[J]. BMC Pregnancy Childbirth,2015,15(1):447~449. [9] Shirazian T, Faris BS, Fox NS, et al. The lifestyle modification project: limiting pregnancy weight gain in obese women[J].Matern Fetal Neonatal Med,2016,29(1):80~84. [10] 张秀群,关海兰. 孕早、中期血清β-HCG、sFlt-1、sEng联合子宫动脉多普勒搏动指数预测子痫前期的诊断价值[J].广西医科大学学报,2015,32(3):448~450. [11] Kim YM, Chaemsaithong P, Romero R, et al. The frequency of acute atherosis in normal pregnancy and preterm labor, preeclampsia, small-for-gestational age, fetal death and midtrimester spontaneous abortion[J].Matern Fetal Neonatal Med,2015,28(17):2001~2009. [12] 苏秀梅,李林娜.妊娠晚期血脂水平与不同类型子痫前期相关性分析[J].中山大学学报(医学科学版),2016,37(3):428~432. [13] 郭冰杰,杨彩梅.子痫前期孕妇的血脂、血糖与维生素A、E的水平及其临床意义[J].广西医学,2017,39(10):1474~1476,1479.
2018, Vol. 24 
冀公网安备13080202000786号