Abstract：Objective: To explore the clinical value of detecting leptin, hypersensitive c-reactive protein in serum in patients with Impaired glucose tolerance and sleep disorders. Methods: Choose hospitalized patients with no history of diabetes from May 2015 to May 2017.The oral glucose tolerance test (OGTT) was tested to assess blood glucose metabolism and Pittsburgh sleep quality index (PSQI)was evaluated to assess sleep status. 72 IGT patients were selected. According to the PSQI score, IGT patients were divided into IGT+ sleep disorder group and IGT+ non-sleep disorder group. In addition, 58 patients with normal glucose tolerance and no sleep disorder were selected as the control group. HsCRP, leptin and pancreas islet function were measured in each group. Results: The median levels of FPG, 2hPG and 2hIns in the IGT with non-sleep disorder group and the IGT with sleep disorder group were higher than those in the control group (P<0.05); the median level of HbA1c and HOMA-IR in IGT with non-sleep disorder group was higher than that in the control group (P<0.05).The median level of Leptin in the IGT with non-sleep disorder group and the IGT with sleep disorder group was higher than that in the control group (P<0.05);The median level of hsCRP in the IGT with sleep disorder group was higher than that in the IGT with non-sleep disorder group, the median hsCRP of the IGT with non-sleep disorder group was higher than that of the control group (all P <0.05).The median level of PSQI in the IGT with sleep disorder group was higher than in the IGT with non- sleep disorder group and the control group (P<0.05).Logistic regression analysis showed that sleep disorders was positively correlated with 2hPG and hsCRP (P<0.05);Hyperinsulinemia, PSQI and glucose tolerance were positively correlated (P<0.05). Conclusion: Levels of hsCRP and leptin were significantly increased in patients with IGT and sleep disorders, inflammation and leptin play a role in sleep disorders, which may further aggravate insulin resistance and thereby increase the risk of glucose tolerance reduction.
刘敏,王兆鹏,冯玉梅,杨新宏,孙常铭,张萍. 瘦素超敏C反应蛋白在糖耐量减低并睡眠障碍患者中的临床意义[J]. 河北医学, 2018, 24(10): 1672-1676.
LIU Min, WANG Zhaopeng, FENG Yumei, et al. Clinical Significance of Detecting Leptin Hypersensitive C-reactive Protein in Patients with Impaired Glucose Tolerance and Sleep Disorders. HeBei Med, 2018, 24(10): 1672-1676.
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2018, Vol. 24 
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