Abstract：Objective: To investigate the effect of argatroban combined with alteplase intravenous thrombolysis in the treatment of acute cerebral infarction and the influence of cerebrovascular reserve function. Results: 122 patients with acute cerebral infarction admitted to our hospital from July 2016 to December 2017 were analyzed retrospectively. All the patients were divided into control group and study group, The patients in control group were treated with alteplase intravenous thrombolytic therapy, and the patients in study group were treated with argatroban. the clinical efficacy. The neurological function score, serum BNP, CRP level and cerebrovascular reserve function were compared between the two groups. Results: The total efficiency of Agha Argatroban combined with intravenous thrombolytic therapy in acute cerebral infarction in the study group was significantly higher than that in the control group (P＜0.05). The clinical efficacy of argatroban combined with alteplase intravenous thrombolysis in the study group was significantly better than that in the control group ( P<0.05 ). There was no significant difference in GCS score and ADL score between the two groups before treatment ( P > 0.05 ). After treatment, GCS score and ADL score of patients with acute cerebral infarction in the study group were significantly higher than those in the control group ( P<0.05 ). There was no significant difference in serum BNP and CRP levels between the two groups before treatment ( P > 0.05 ). after treatment, the serum BNP and CRP levels in the study group were significantly lower than those in the control group ( P<0.05 ). There was no significant difference in cerebrovascular reserve function between the two groups before treatment ( P > 0.05 ), and the cerebrovascular reserve function of the study group was significantly better than that of the control group after treatment ( P<0.05 ). Conclusion: Argatroban combined with alteplase intravenous thrombolysis in the treatment of acute cerebral infarction curative effect is remarkable. It can effectively strengthen the patient's nerve function and cerebrovascular reserve function, and improve the serum BNP, CRP levels, safe and reliable, It's worthy of clinical promotion.
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2018, Vol. 24 
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