Abstract：Objective: To investigate the effects of Liraglutide on myocardial fibrosis in rats after acute myocardial infarction (AMI). Methods: The rat model of AMI was established by occlusion of the left anterior descending artery. The AMI rats were randomly divided into 3 groups: Control group (n=6), Low dose liraglutide (LS) group (n=6, 0.09mg·kg-1·d-1) and high dose liraglutide (HS) group (n=6, 0.18mg·kg-1·d-1). Sham operation group (n=6), rats received normal saline. 4 weeks later, cardiac structure and function were assessed by echocardiography; collagen volume fraction was calculated by Sirius-redstaining; the apoptotic myocardial cells were detected by TUNEL method; Pro caspase3, cleaved caspase3, PARP, TGF-β and MMP-9 were determined by Western blotting. Results: Compared with Sham operation group, control group showed decreased LVEF, LVFS and increased LVEDd, LVESd (P<0.05). Compared with control group, LS group and HS group had obviously increased LVEF, LVFS and decreased LVEDd, LVESd (P<0.05). Collagen volume fraction and apoptotic index were significantly decreased in LS group and HS group when compared with control group (P<0.05). The expression of Pro caspase3, cleaved caspase3, PARP, TGF-β and MMP-9 were significantly decreased in LS group and HS group in compared with control group (P<0.05). Conclusion: Liraglutide can reduce myocardial fibrosis in rats after AMI which partly contributes to attenuate the expression of TGF-β and MMP-9 and reduce myocardial cell apoptosis.
乔慧瑛,周文青,任海燕,周茜. 利拉鲁肽对急性心肌梗死大鼠心肌纤维化影响的实验研究[J]. 河北医学, 2018, 24(10): 1585-1588.
QIAO Huiying, et al. Experimental Study of Inhibited Myocardial Fibrosis by Liraglutide Following Acute Myocardial Infarction in Rats. HeBei Med, 2018, 24(10): 1585-1588.
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2018, Vol. 24 
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