Abstract：Objective: To observe the changes of renin, angiotensin II (ATII) and aldosterone (ALD) in plasma of patients with acute myocardial infarction (AMI) at different sites of infarction. Methods: A total of 49 patients with anterior wall AMI, 39 patients with inferior wall AMI, 29 patients with acute non-ST segment elevation myocardial infarction (NSTEMI) and 20 patients with unstable angina pectoris (UA) were enrolled in this study. (BNP), left ventricular end-diastolic diameter (LV), ejection fraction (EF) and so on were recorded and compared between the two groups. Results: Renin 16.73 (8.42, 33.12) in the anterior wall AMI group, Renin 18.98 (8.30,30.41) in the inferior wall AMI group and Renin 15.27 (P = 0.009) in the NSTEMI group were significantly higher than those in the UA group (P <0.05). There was no significant difference between the two groups (P> 0.05). There was no significant difference in the level of Renin between the two groups (P> 0.05). Renin and ATII were correlated with Rs = 0.157 (P <0.05). ALD was correlated with ATII (Rs = 0.325, P <0.01). Conclusion: The level of Renin in the early stage of AMI was higher than that in the control group. There was no significant difference in the Renin level between the two groups. There was no significant difference in ATII and ALD between the two groups, but there was correlation between Renin, ATII and ALD.
李舒承, 王虹, 刘超, 张爱文. 不同部位心肌梗死急性期肾素血管紧张素醛固酮变化分析[J]. 河北医学, 2018, 24(1): 90-95.
LI Shucheng, WANG Hong, LIU Chao, et al. Changes of Rennin Angiotensin Aldosterone in Acute Myocardial Infarction in Different Parts. HeBei Med, 2018, 24(1): 90-95.
[1] 熊力,罗斌华,王南丽,等.肾素-血管紧张素-醛固酮系统与急性心肌梗死短期预后关系的研究[J].中国循证心血管医学杂志,2014,6(1):92~94. [2] Shearer F,Lang CC,Struthers AD.Renin angiotensin aldosterone system inhibitors in heart failure[J].Clin PharmacolTher,2013,94(4):459~467. [3] Qian Q,Manning DM,Ou N,et al.ACEi/ARB for systolic heart failure:closing the quality gap with a sustainable intervention at an academic medical center[J].Hosp Med,2011,6(3):156~ 160. [4] Sawhney JP.Angiotensine converting enzyme inhibitors in acute myocardial infarction-a review[J].Indian Heart,2011,63(1):71~78. [5] Amsterdam,Ezra A. MD,FACC; et al. 2014 AHA/ACC guideline for the management of patients with Non-ST-Elevation acute coronary syndromes: a report of the american college of cardiology/american heart association task force on practice guidelines[J].Circulation,2014,130(25):e344~ e426. [6] 颜勇,杨庭树,苗冬梅,等.再血管化治疗对急性心肌梗死患者血浆激素水平和心功能的影响[J].中国循环杂志,2004,19(1):31~33. [7] 张雪松,刘淑琴,刘忠志,等.药物与择期PCI治疗对急性ST段抬高型心肌梗死患者交感神经及RAAS系统的影响[J].山东医药,2012,52(37):58~60. [8] 吴春涛.醛固酮对急性心肌梗死后左心室重构影响的研究进展[J].心血管病学进展,2011,32(3):365~367. [9] 张莉芳.醛固酮受体拮抗剂在慢性心力衰竭中的应用[J].中国现代药物应用,2012,6(11):66~67. [10] 李舒承,郝玉明,郭金锐,等.早期再灌注治疗对ST段抬高型心肌梗死患者白细胞的影响[J].天津医药,2014,42(4):349~351. [11] Zile MR,Colombo PC,Mehra M,et al.Progressive improvement in cardiac performance with continuous aortic flow augmentation (aortic flow therapy) in patients hospitalized with severe heart failure:results of the Multicenter Trial of the Orqis Medical Cancion System for the Enhanced Treatment of Heart Failure Unresponsive to Medical Therapy (MOMENTUM)[J].Heart Lung Transplant,2010,29(1):86~92.
2018, Vol. 24 
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