Abstract：Objective: To study the effects of dexmedetomidine and propofol in patients with liver and kidney function, blood gas analysis of craniocerebral injury. Methods: 80 cases of craniocerebral injury admitted in our hospital from November 2012 to November 2017 (40 cases of normal liver and kidney function, 40 cases of abnormal liver and kidney function) were retrospectively studied. According to the random number table method, 40 cases of patients with normal liver function were divided into group A and group B, each of 20 cases; 40 cases of liver and kidney dysfunction were divided into group C and group D, each of 20 cases. Group A and group C were anesthetized with dexmedetomidine combined with propofol, and group B and D were used to induce anesthesia by propofol alone. The general data of all patients (gender, age, BMI, ASA score, and operation time) were counted; The liver function (AST, ALT), renal function (serum creatinine, blood urea nitrogen) and blood gas analysis (PaO2 and PaCO2) were detected before operation (T1), 12h (T2) after operation and 24h (T3) after operation. Results: There was no significant changes of AST and ALT in 12h and 24h after operation (P > 0.05). There was no significant difference in AST and ALT between group A and group B, group C and group D at the same time point (P > 0.05). 12h and 24h after operation, the BUN and Scr were significantly increased (P < 0.05). The blood urea nitrogen and serum creatinine levels in the group A were significantly lower than those in the group B (P < 0.05), and the group C was significantly lower than that in the group D (P < 0.05). After operation, all the patients in each group decreased significantly (P < 0.05) and PaCO2 significantly increased (P < 0.05). At the same time point, the PaO2 value of group A was higher than that of group B (P < 0.05), and the C group was significantly higher than that of group D (P < 0.05), PaCO2 value in group A was significantly lower than that of group B (P < 0.05). Conclusion: Dexmedetomidine combined with propofol can improve renal function and blood gas analysis in patients with craniocerebral injury, but has no obvious protective effect on liver and little effect on liver function.
曹桂珍, 殷乐, 陈建均. 肾癌患者右美托咪定复合丙泊酚对颅脑损伤患者肝肾功能血气分析的影响[J]. 河北医学, 2018, 24(1): 38-43.
CAO Guizhen, YIN Le, CHEN Jianjun. Effects of Dexmedetomidine Combined with Propofol on Liver and Kidney Function and Blood Gas Analysis in Patients with Brain Injury. HeBei Med, 2018, 24(1): 38-43.
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2018, Vol. 24 
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