Abstract：Objective: To research the changes and significance of serum von hippel-lindau (VHL), hypoxia-inducible factor (HIF)-1α and HIF-2α in patients with renal cancer. Method: 45 cases of renal carcinoma were collected from January 2015 to April 2016 as the renal cell cancer group, and at the same time the collection of healthy persons as control group, serum VHL, HIF-1α and HIF-2α level of two groups were examined; The maximum diameter of renal cancer patients was measured; Patients with renal cell carcinoma were followed up for 6 months, observed and recorded the recurrence patients. Results: The level of serum VHL in renal cancer group decreased significantly compared with that in control group, while levels of HIF-1α and HIF-2α were obviously higher( P<0.01) . Expression of serum VHL, HIF-1α and HIF-2α was not related to age and sex in renal carcinoma (P>0. 05) ,while there was significantly correlated with pathological grade, clinical stages, diameter of cancer site and lym-phatic metastasis (P<0.01). Level of serum VHL in recurrent cases was obviously lower, while levels of HIF-1α and HIF-2α were obviously higher than non-recurrent cases( P< 0.05,P<0.01) . Conclusion: Levels of serum VHL, HIF-1α and HIF-2α are correlated significantly with pathological grade, clinical stages, size of carcinoma and lymphatic metastasis, which indicates indexes mentioned above could be play an important role in the occurrence and development of clear cell renal carcinoma.
史春夏, 李忠心, 刘永泉, 张会敏. 肾癌患者血清VHL HIF-1α HIF-2α水平变化及意义[J]. 河北医学, 2018, 24(1): 34-38.
SHI Chunxia, LI Zhongxin, LIU Yongquan, et al. The Level Changes and Significance of Serum VH HIF-1α and HIF-2α Levels in Patients with Kidney Cancer. HeBei Med, 2018, 24(1): 34-38.
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2018, Vol. 24 
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