Abstract：Objective: To observe the changes of serum levels of Th1/Th2 cytokin before and after the treatment of ulcerative colitis (UC). Methods: 58 patients with active UC were selected into UC group while 58 healthy persons as control group. The expression of IL-2、IFN-γ、IL-4、IL-10 in serum were measured at the 3 different time points: before treatment, 3 months and 12 months after treatment. Results: Before treatment, the expression of IFN-γ、IL-10 in serum decreased but IL-4 increased in UC group, with statistical differences (P<0.05). 3 months and 12 months after treatment, the expression of IFN-γ in UC group was lower significantly than control group, but no statistical difference was found in UC group. The expression of IL-4 was higher significantly than control group, especially at the time point of 12 months after treatment (P<0.05). The expression of IL-10 was lower than control group, but it increased significantly at the time point of 12 months after treatment (P<0.05). There was no statistical difference in the expression of IL-2 between the two groups (P>0.05). Conclusion: It was suggested that the expression of IFN-γ decreased and IL-4 increased in serum during active UC, would inhibit the Th1 cells immune response to limit inflammatory process. During the remission of UC, the expression of IL-4 decreased and IL-10 increased would keep the balance of Th1/Th2 cells gradually.
王玮, 谭玉婷, 罗丹, 李启祥, 尹合坤. Th1/Th2细胞因子在初发型溃疡性结肠炎治疗前后的血清水平变化[J]. 河北医学, 2018, 24(1): 167-170.
WANG Wei, TAN Yuting, LUO Dan, et al. The Changes of Serum Levels of Th1/Th2 Cytokines before and after the Treatment of Active Ulcerative Colitis. HeBei Med, 2018, 24(1): 167-170.
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2018, Vol. 24 
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