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河北医学  2018, Vol. 24 Issue (1): 155-158    DOI: 10.3969/j.issn.1006-6233.2018.01.041
  临床研究 本期目录 | 过刊浏览 | 高级检索 |
探讨chemerin和CRP与妊娠期糖尿病的相关性研究
廉航1, 魏艳玲2
1.铜川矿务局中心医院妇产科, 陕西 铜川 727000;
2.第四军医大学唐都医院妇产科, 陕西 西安 710038
Study on the Correlation between Chemerin and CRP and Gestational Diabetes
LIAN Hang, et al
The Central Hospital of Tongchuan Mining Bureau, Shaanxi Tongchuan 727000, China
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摘要 目的: 探讨趋化素(chemerin)和C反应蛋白(CRP)在妊娠期糖尿病患者血清中的水平及其临床意义。方法: 选取2016年3月至2017年2月疑似妊娠期糖尿病女性100例,根据妊娠期糖尿病诊断结果,分为糖尿病组(40例)和非糖尿病组(60例),同时选取同期健康非妊娠女性50例为对照组,采用酶联免疫吸附试验检测所有研究对象血清chemerin和CRP表达水平及探讨其临床意义。结果: 对照组与非糖尿病组血清chemerin、CRP、FBG、1h FBG、2 hFBG及3 hFBG水平比较,差异无统计学意义(P>0.05);糖尿病组血清chemerin、CRP、FBG、1h FBG、2 hFBG及3 hFBG水平均高非糖尿病组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血清chemerin和CRP水平诊断妊娠期糖尿病具有良好的评估价值。结论: 妊娠期糖尿病患者血清chemerin和CRP呈高水平状态,检测孕妇血清chemerin和CRP水平对妊娠期糖尿病筛查诊断具有一定的临床价值。
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廉航
魏艳玲
关键词 妊娠期糖尿病趋化素C反应蛋白    
AbstractObjective: To discuss the levels and clinical significance of chemerin and CRP in the serum of gestational diabetes patients. Methods: From March 2016 to February 2017, 100 suspected gestational diabetes women were selected. According to the diagnosis of gestational diabetes, all women were divided into diabetes group (40 cases) and non-diabetic group (60 cases). At the same time, 50 cases of healthy non-pregnant women were selected as control group. The serum chemerin and CRP expression levels of all subjects were tested by enzyme-linked immunosorbent assay and its clinical significance was discussed. Results: Comparison of serum chemerin, CRP, FBG, 1h FBG, 2 hFBG and 3 hFBG levels in the control group and non-diabetic group, the difference was not statistically significant (P>0.05). The serum chemerin, CRP, FBG, 1h FBG, 2 hFBG and 3 hFBG levels of the diabetic group were all high non-diabetic group, and the difference was statistically significant (P<0.05). The results of ROC curve analysis showed that serum chemerin and CRP level diagnosis of gestational diabetes had good evaluation value. Conclusions: The serum chemerin and CRP in gestational diabetes are at a high level, and the detection of serum chemerin and CRP in pregnant women has certain clinical value in the diagnosis of gestational diabetes.
Key wordsGestational diabetes    Chemerin    CRP
    
基金资助:陕西省自然科学基金项目,(编号:2008c252)
通讯作者: 魏艳玲   
引用本文:   
廉航, 魏艳玲. 探讨chemerin和CRP与妊娠期糖尿病的相关性研究[J]. 河北医学, 2018, 24(1): 155-158.
LIAN Hang, et al. Study on the Correlation between Chemerin and CRP and Gestational Diabetes. HeBei Med, 2018, 24(1): 155-158.
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