Abstract：Objective: To investigate the efficacy of rosuvastatin combined with fenofibrate in the treatment of type 2 diabetes with hyperlipidemia. Methods: 80 patients with type 2 diabetes mellitus complicated with hyperlipidemia enrolled in our hospital from September 2014 to September 2016 were randomly divided into two groups. 40 patients in the control group were treated with rosuvastatin alone. The experimental group 40 Patients were treated with rosuvastatin combined with fenofibrate, and the overall efficacy was compared between the two groups before and after treatment. Results: The total effective rate was 85.5% and 97.5% in the control group and experimental group. The total effective rate in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion: Risuvastatin combined with fenofibrate has a good therapeutic effect in the treatment of type 2 diabetes mellitus with hyperlipidemia. The effective rate of treatment is improved, and low fat lipoprotein cholesterol is reduced, and the level of blood lipid is improved and the safety is higher, which provide a theoretical basis for clinical research.
孙晔子, 沈莉敏, 孙欢欢, 周吉, 曹小俊. 瑞舒伐他汀联合非诺贝特治疗2型糖尿病合并高脂血症的疗效观察[J]. 河北医学, 2017, 23(9): 1419-1422.
SUN Yezi, SHEN Limin, SUN Huanhuan, et al. Effect of Rosuvastatin Combined with Fenofibrate on Type 2 Diabetes Mellitus Complicated with Hyperlipidemia. 河北医学, 2017, 23(9): 1419-1422.
[1] 刘小平.瑞舒伐他汀纠正早期糖尿病肾病并发高脂血症患者的血脂代谢紊乱的临床研究[J].中国药房,2012,23(2):145~146. [2] 周红坚,周雪坚,雷娇杨.瑞舒伐他汀对老年糖尿病肾病血清脂蛋白a水平的影响[J].中国临床医生,2010,39(10):30~32. [3] 杨旻晟,李建平,方琪.瑞舒伐他汀对缺血性脑卒中合并糖尿病患者血脂水平的影响[J].现代中西医结合杂志,2012,21(34):3829~3830. [4] 宋洁,王文平,丁晓洁,等.瑞舒伐他汀对老年2型糖尿病脂代谢紊乱患者血脂、Hcy、hs-CRP的影响[J].安徽医药,2015,19(5):997~999. [5] 张志平.氟伐他汀联合非诺贝特治疗糖尿病高血脂的疗效分析[J].中国医药导刊,2012,14(6):1042~1043. [6] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版)[J].中国糖尿病杂志,2012,20(1):81~117. [7] 诸骏仁,高润霖,赵水平,等.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志,2016,31(10):937~953. [8] 郭志红.大剂量辛伐他汀与其联合非诺贝特对糖尿病高脂血症患者降脂疗效的临床观察[J].中国临床保健杂志,2011,14(4):425~426. [9] Adsule Samir Maruti,BaigMirzaShiraz,Gade P R,et al.A comparative evaluation of safety and efficacy of rosuvastatin,simvastatin,and atorvastatin in patients of type 2 diabetes mellitus with dyslipidemia[J].International Journal of Diabetes in Developing Countries,2010,29(2):74~79. [10] 吴剑利.瑞舒伐他汀对2型糖尿病患者的降脂疗效及血管内皮功能的影响[J].中国现代医生,2014,52(6):63~65. [11] 王媛媛,吴丹静,李艳伟.瑞舒伐他汀联合依折麦布治疗老年糖尿病并发高脂血症的临床疗效[J].中国老年学杂志,2016,36(6):1358~1359. [12] 夏杰.瑞舒伐他汀对糖尿病高胆固醇血症患者血脂及炎症因子的影响[J].海南医学院学报,2017,23(4):501~503. [13] Hsieh Ching Jung,Huang Bin.Rosuvastatin decreases testosterone levels but not sexual function in men with type 2 diabetes[J].Diabetes Research and Clinical Practice,2016,120:81~88. [14] 王秀梅.不同剂量辛伐他汀联合非诺贝特治疗2型糖尿病合并高脂血症的临床疗效[J].现代药物与临床,2014,0(11):1249~1252. [15] 张红霞.瑞舒伐他汀用于糖尿病肾病合并高脂血症患者效果观察[J].山东医药,2011,51(15):88~89. [16] 王艳梅.瑞舒伐他汀对2型糖尿病患者低密度脂蛋白胆固醇和高敏C反应蛋白的影响[J].中国老年学杂志,2012,32(12):2588~2589. [17] Dugani Sagar B,Akinkuolie Akintunde O,Paynter Nina,et al.Association of lipoproteins,insulin resistance,and rosuvastatin with incident type 2 diabetes mellitus:secondary analysis of a randomized clinical trial[J].JAMA Cardiology,2016,1(2):136~145. [18] 夏晓琳,陈霞,郑炜.氟伐他汀联合非诺贝特治疗糖尿病合并高血脂症100例[J].中国药业,2015,24(11):113~114. [19] 谭章华.氟伐他汀和非诺贝特治疗糖尿病合并高血脂症疗效观察[J].现代中西医结合杂志,2014,23(4):395~397.
2017, Vol. 23 
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