Abstract：Objective: To investigate the relationship between the expression of MICA gene in bladder cancer and the mutation of p53 gene and K-ras gene. Methods: 66 cases of bladder cancer patients with clinical data in our hospital from March 2014 to March 2016 were analyzed. Semi quantitative PCR-SSCP technique was used to detect the expression of MDR1 gene and p53 and K-ras in cancer tissues, and analyzed the relationship between the expression of MICA gene in colorectal cancer and the mutation of p53 and K-ras genes. Results: The study found that there was no correlation between the expression of MICA and the location, age and sex of the patients with colorectal cancer (P > 0.05). In 66 patients, the mean expression of MICA in 22 lymph node metastasis patients was higher than that without lymph node metastasis, and the difference was statistically significant (P < 0.05). 8 cases of K-ras and p53 gene expression of the MICA gene mutation combined with average weight is higher than non mutation, the difference was statistically significant (P < 0.05), 12 cases of K-ras gene mutation MICA average expression was slightly higher than that without mutation, but the difference was not statistically significant (P > 0.05), 16 cases of p53 gene mutation MICA expression was significantly better than the average mutation in the p53 gene, the difference was statistically significant (P < 0.05). Conclusion: The high expression of MICA gene has become a key indicator for the detection of bladder cancer, and the correlation between K-ras and p53 gene and its high expression.
谷敬锋, 王桂琦, 刘海霞, 高英超, 王园园. 结直肠癌MICA基因的表达与p53 K-ras基因突变的关系研究[J]. 河北医学, 2017, 23(8): 1233-1235.
GU Jingfeng, WANG Guiqi, et al. The Relationship between MICA Gene Expression of Bladder Cancer and Mutation of p53 and K-ras Gene. HeBei Med, 2017, 23(8): 1233-1235.
2017, Vol. 23 
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