Abstract：Objective: To investigate the effect of intravitreal injection of monoclonal antibody on the postoperative visual acuity in patients with proliferative diabetic retinopathy. Methods: 110 patients with proliferative diabetic retinopathy treated by minimally invasive incision treatment of vitreous body were randomly divided into two groups, 55 cases, 96 eyes of patients in the experimental group, the control group of 55 cases, 102 eyes of two patients underwent minimally invasive vitreous body incision, the patients in the experimental group before surgery given ranibizumab. The vascular endothelial growth factor (VEGF),visual acuity,the operation time, bleeding, and the efficiency of clinical treatment between the two groups before and after treatment were observed and compared. Results: Compared with before treatment, the level of VEGF decreased and visual acuity increased in the two groups after treatment, and the difference was statistically significant (P<0.05); Compared with the control group, the patients in the experimental group had lower VEGF levels and higher visual acuity, and the difference was statistically significant (P<0.05); Compared with the control group, the operation time of the experimental group was shorter, the rate of operation bleeding was lower, and the effective rate of clinical treatment was higher, the difference was statistically significant (P<0.05). Conclusion: Intravitreal injection can significantly improve the postoperative VEGF and visual acuity in patients with proliferative diabetic retinopathy, the bleeding rate is low, and the clinical effect is better.
2017, Vol. 23 
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