右美托咪定联合脑电双频指数监测应用于肺癌根治术患者对全麻苏醒及拔管期血流动力学影响研究

doi:10.3969/j.issn.1006-6233.2017.07.004

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摘要 目的: 探讨右美托咪定联合脑电双频指数监测应用于肺癌根治术患者对全麻苏醒及拔管期血流动力学影响。方法: 选择本院于2016年1月至2016年12月收治的需行肺癌根治术患者60例入选本研究,均给予等剂量右美托咪定等药物行麻醉诱导,术中根据临床经验泵注丙泊酚、瑞芬太尼及间断静注顺-阿曲库铵维持麻醉深度;观察组30例术中维持脑电双频指数(BIS)于40~60之间,根据监测结果调整丙泊酚用量。比较两组呼吸及意识恢复时间、麻醉药物总量,观察两组拔管期间血流动力学指标变化情况,并统计两组不良反应发生率。结果: 观察组血流动力学更为平稳(P<0.05);观察组丙泊酚总量、瑞芬太尼总量均显著低于对照组(P均<0.05);观察组呼吸恢复时间、拔管时间、定向力恢复时间显著低于对照组(P<0.05);观察组拔管期间不良反应发生率显著低于对照组(P<0.05)。结论: 右美托咪定联合脑电双频指数监测应用于肺癌根治术患者血流动力学平稳,可降低麻醉药物使用总量,苏醒时间缩短,且安全。

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	陈孟
	何欢
	李德春
	梁勇升

关键词 ：右美托咪定, 脑电双频指数, 肺癌根治术, 苏醒时间

Abstract：Objective: To investigate the effects of dexmedetomidine combined with bispectral index applied on hemodynamics of patients with lung cancer effects during anesthesia recovery period and pull. Methods: 60 patients admitted in our hospital from January to December 2016 enrolled in this study were the need for radical lung cancer, were given the same dose of dexmedetomidine and other drugs for induction of anesthesia, surgery according to the clinical experience of infusion of propofol, remifentanil and intermittent intravenous injection of CIS atracurium to maintain the depth of anesthesia. In the observation group, 30 cases maintained bispectral index (BIS) between 40 and 60, and adjusted the amount of propofol according to the monitoring results. The respiratory and consciousness recovery time and the total amount of narcotic drugs were compared between the 2 groups. The hemodynamic indexes of the 2 groups were observed during the extubation, and the incidence of adverse reactions in the 2 groups was counted. Results: The hemodynamics observation group' is more stable (P<0.05); The total amount of remifentanil, were significantly lower than the control group (P <0.05); the observation group breathing recovery time, extubation time, orientation recovery time was significantly lower than the control group (P<0.05); the incidence of adverse reaction the observation group during the extubation was significantly lower than the control group (P<0.05). Conclusion: Dexmedetomidine combined with bispectral index in lung cancer patients blood flow dynamics is stable, can reduce the total use of narcotic drugs, recovery time shortened, and safety.

Key words： Dexmedetomidine Bispectral index Radical resection of lung cancer Recovery time

基金资助:广西壮族自治区玉林市科技课题,(编号:ylkj20162901)

通讯作者: 梁勇升

引用本文:

陈孟, 何欢, 李德春, 梁勇升. 右美托咪定联合脑电双频指数监测应用于肺癌根治术患者对全麻苏醒及拔管期血流动力学影响研究[J]. 河北医学, 2017, 23(7): 1067-1069.
CHEN Meng, HE Huan, LI Dechun, et al. Dexmedetomidine Combined with Bispectral Index Monitoring on Hemodynamics during General Anesthesia Recovery and Extubation in Patients Undergoing Radical Resection of Lung Cancer. HeBei Med, 2017, 23(7): 1067-1069.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2017.07.004 或 http://www.hbyxzzs.cn/CN/Y2017/V23/I7/1067

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