难治性部分性癫痫应用加巴喷丁添加治疗的疗效及安全性分析

doi:10.3969/j.issn.1006-6233.2017.06.013

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摘要 目的: 探究难治性部分性癫痫应用加巴喷丁添加治疗的疗效及安全性。方法: 收集我院神经内科收治的难治性部分性癫痫患者70例,随机分为试验组和对照组,各35例。对照组患者予以卡马西平片起始剂量为5mg/kg每日,可逐渐增至20mg/kg;托吡酯片起始剂量为0.8mg/kg每日,可逐渐增至7mg/kg。试验组患者在维持对照组用药的基础上添加加巴喷丁胶囊,第1日加巴喷丁胶囊300mg口服每次,每日1次,第二日剂量加巴喷丁胶囊300mg口服每次,每日2次,第3天直至疗程结束为加巴喷丁胶囊300mg口服每次,每日3次。两组患者疗程均为6个月。治疗结束后对两组患者临床疗效、记忆功能、神经功能缺损程度、T淋巴细胞群、血清免疫球蛋白及不良反应发生情况进行对比。结果: 治疗后,与基线期发作频率相比,两组4周后发作频率以及12周后发作频率较低;与治疗前相比,治疗后两组CMS得分升高,NFDS得分降低,IgA、IgG以及IgM水平降低,血清CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺升高(P＜0.05)。与对照组相比,试验组临床总有效率较高,4周后、12周后发作频率较低,CMS得分较高,NFDS得分较低,IgA、IgG以及IgM水平较低,血清CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺较高,不良反应发生率较低,差异具有统计学意义(P＜0.05)。两组治疗前后CD⁸⁺相比,差异无统计学意义(P＞0.05)。结论: 加巴喷丁添加治疗难治性部分性癫痫的临床疗效显著,能够改善患者记忆功能、神经功能及免疫功能,安全性高,适宜临床应用推广。

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关键词 ：难治性部分性癫痫, 加巴喷丁, 临床有效率, 安全性

Abstract：Objective: To investigate the efficacy and safety analysis of Gaba Martin Add treatment in the treatment of Refractory partial epilepsy patients. Method: 70 Refractory partial epilepsy patients admitted to neurology department of our hospital were selected and randomly divided into the control group and the experiment group with 35 cases in each group. The control group was given a Carbamazepine Tablets starting dose of 5mg/kg daily, gradually increased to 20 mg/kg. Topiramate Tablets starting dose of 0.8mg/kg per day could be gradually increased to 7mg/kg. The patients in the experimental group were added gabapentin Capsule on the basis of the control group. First gabapentin capsules 300mg orally every time, 1 times a day, second doses of gabapentin capsules 300mg orally every day, 2 times a day, third days until the end of treatment for gabapentin capsules 300mg oral every time, 3 times a day. Two groups of patients were treated for a period of 6 months. After treatment, the clinical efficacy, memory function, the degree of neurological deficit, T lymphocyte group, serum immunoglobulin and adverse reactions were compared between the two groups. Results: After treatment, 2 weeks after the onset of the attack frequency and the frequency of attack after 12 weeks was lower than the baseline frequency. Compared with before treatment, after treatment, the 2 groups of CMS score increased, NFDS score decreased, IgA, IgG and IgM levels decreased, serum CD³⁺, CD⁴⁺, CD⁴⁺/ CD⁸⁺ increased(P＜0.05). Compared with the control group, the total effective rate of treatment group was higher after 4 weeks, 12 weeks after the onset of lower frequency, higher CMS scores, lower NFDS score, IgA, IgG and IgM low level of serum CD³⁺, CD⁴⁺, CD⁴⁺/, CD⁸⁺ high and low incidence rate of adverse reaction, the difference has statistical significance(P＜0.05). There was no significant difference between the 2 groups before and after treatment with CD⁸⁺(P＞0.05). Conclusion: The clinical efficacy of gabapentin in the treatment of refractory partial epilepsy is significant. It can improve the memory function, nerve function and immune function of patients.

Key words： Refractory partial epilepsy Gaba martin Clinical efficacy Safety

基金资助:山东省卫生厅科研项目,(编号:2013ZR2786)

引用本文:

邵广田, 邵璐斐, 陈霄雷, 任显芝, 崔凤荣. 难治性部分性癫痫应用加巴喷丁添加治疗的疗效及安全性分析[J]. 河北医学, 2017, 23(6): 923-926.
SHAO Guangtian, et al. Efficacy and Safety Analysis of Gaba Martin Add treatment in the Treatment of Refractory Partial Epilepsy Patients. 河北医学, 2017, 23(6): 923-926.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2017.06.013 或 http://www.hbyxzzs.cn/CN/Y2017/V23/I6/923