Abstract：Objective: To investigate the inhibition of inflammation by cannabidiol in a mouse model of spinal cord injury and study its mechanism. Methords: 24 male C57Bl/6 mice were randomized into 3 groups: sham-operation group, control group and medication group. We established an spinal cord injury model by clip method, the mice in sham-operate group and control group were administered with a mixture of 1% of tween 80 and sterile saline (0.25mL/10g) and medication group were treated with cannabidiol (30mg/kg ; was dissolved in a mixture of 1% of Tween 80 and sterile saline (1.2mg/mL)) by intraperitioneal injection at 1h、12h、24h、36h、48h、60h after operation.72h after operation , BMS test was used to evaluate the neurological score, the expression levels of HMGB1 and TNF-αin spinal cord tissue were assayed by ELISA. Rsults: The BMS test showed that medication group had a higher score than the control group(P<0.05). The expression levels of HMGB1 and TNF-α in medication group were significant reduced as comparison with control group P<0.05), but significant increased than the sham-operation group(P<0.05). Conclusion: Cannabidiol can inhibit inflammation in a mouse model of spinal cord injury via inhibiting the expression of HMGB1.
李萃萃, 张曼辉, 夏涵, 戴宜武. 大麻二酚抑制小鼠脊髓损伤后炎症反应及促进功能恢复的研究[J]. 河北医学, 2017, 23(5): 767-769.
LI Cuicui, et al. Cannabidiol Can Inhibit Inflammation in a Mouse Model of Spinal Cord Injury. 河北医学, 2017, 23(5): 767-769.
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2017, Vol. 23 
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