Abstract：Objective: To study effect and its influence of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) of erythropoietin and methylprednisolone in the treatment of patients with acute interstitial nephritis. Methods: 96 patients with AIN who were treated in our hospital from January 2015 to December 2016 were selected as study object. The patients were divided into observation group and control group with 48 cases in each group. The two groups were discontinued may lead to AIN drugs, and corrected the acidosis, while maintained the body of water electrolyte balance. The control group was given methylprednisolone, modified Chengponisong oral in the treatment of 3d, the observation group was another given EPO for treatment. Two groups were treated for 1 month then compared the comparison of efficacy, clinical indicators, adverse reactions, and the two groups before treatment and after treatment of IL-6 and TNF-α level. Results: The effective rate of the observation group was 43.75%, and the total effective rate was about 97.92%, respectively compared with the control group of 16.67% and 83.33% were significantly higher, the difference was statistically significant (P < 0.05). In the observation group, the time of oliguria, the time of polyuria, the time of disappearance of hematuria and proteinuria, and the recovery of renal function to normal were significantly less than those in the control group, the difference was statistically significant (P < 0.05). After treatment, the levels of IL-6 and TNF-α in two groups were significantly lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P < 0.05). The total incidence of adverse reactions in the observation group was 10.42%, compared with the control group of 12.50%, the difference was not statistically significant (P > 0.05). Conclusion: The application of EPO and methylprednisolone on the curative effect of treatment of AIN patients with better implementation of the high safety, reduce the release of inflammatory cytokines and anti-inflammatory action. It is worthy of application and popularization.
刘绥军, 张芙萍. 促红细胞生成素联合甲泼尼龙对急性间质性肾炎患者的疗效及IL-6 TNF-α水平的影响[J]. 河北医学, 2017, 23(4): 580-583.
LIU Suijun, et al. Effect and Influence of Erythropoietin and Methylprednisolone on Acute Interstitial Nephritis patients and IL-6 TNF- alpha. 河北医学, 2017, 23(4): 580-583.
[1] 厉洪江.百令胶囊联合甲泼尼龙治疗儿童急性间质性肾炎的临床疗效及对患儿尿ALB、β2-MG水平的影响[J].国际医药卫生导报,2016,22(15):2258~2261. [2] Oh SS, Choi MW, Choi MR,et al.Acute interstitial nephritis induced by Solanum nigrum[J].Kidney Res Clin Pract,2016,35(4):252~254. [3] 马焕新.左卡尼丁联合促红细胞生成素治疗肾性贫血[J].河北联合大学学报(医学版),2013,15(4):511~512. [4] Belliere J, Meyer N, Mazieres J,et al.Acute interstitial nephritis related to immune checkpoint inhibitors[J].Br Cancer,2016,115(12):1457~1461. [5] 郑栓.66例急性间质性肾炎患者的临床治疗分析[J].医药前沿,2014,1(2):233~234. [6] Rathod N, Pai P.Ertapenem-Induced Acute Interstitial Nephritis (AIN) in a Case of Protein S Deficiency and Factor V Leiden Mutation with Deep Vein Thrombosis[J].Assoc Physicians India,2016,64(3):85~86. [7] 王旭.急性间质性肾炎112例临床分析[J].检验医学与临床,2013,10(21):2861~2862. [8] Biro E, Szikszay E, Peth-Orosz P,et al.Acute interstitial nephritis in T-cell leukemia in a pediatric patient[J].Pediatr Int,2016,58(9):940~942. [9] 李爱霞,刘嵘,邓莎莎,等.促红细胞生成素联合甲泼尼龙治疗急性间质性肾炎的疗效研究[J].湖北科技学院学报(医学版),2016,30(1):28~29. [10] Matta A, Assalie NA, Gupta RK,et al.A rare case of lamotrigine-induced acute interstitial nephritis[J].Community Hosp Intern Med Perspect,2016,6(6):32976~32977. [11] 程子水.促红细胞生成素联合激素治疗AIN28例临床疗效观察[J].中国初级卫生保健,2013,27(5):123~124. [12] 潘淑杰,施海涛,范经絮,等.促红细胞生成素联合甲泼尼龙治疗急性间质性肾炎的疗效分析[J].中国现代药物应用,2016,10(14):139~140. [13] Sandys V, Byrne D.Acute Interstitial Nephritis Secondary to Metamizole; The Rise of Drug Tourism[J].Ir Med,2016,109(7):445~446. [14] 王梦云,丁一波,蒋华,等.促红细胞生成素联合甲泼尼龙治疗急性药物性间质性肾炎的疗效分析[J].现代实用医学,2014,26(9):1098~1100.
2017, Vol. 23 
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