Abstract:Objective: To investigate the efficacy of ulinastatin combined with continuous intravenous hemodialysis in the treatment of severe acute pancreatitis. Methods: 80 patients with severe acute pancreatitis who were enrolled from January 2014 to November 2016 were randomly divided into two groups. The patients in the control group received continuous intravenous hemodialysis and hemodialysis. The patients in the experimental group received ulinastatin combined with continuous intravenous hemodialysis. The disease-related parameters, clinical symptoms remission rate, remission time and overall treatment of two groups patients before and after treatment were compared. Results: The scores of Scr, BUN, TBil, ALT, Lac and CRP in the experimental group were significantly lower than those in the control group (P <0.01); The total effective rate was significantly higher than the control group, there was a significant difference (P <0.05). Conclusion: Ulinastatin combined with continuous static - venous hemodiafiltration in the treatment of severe acute pancreatitis is significant, with reference.
王齐, 卢成康, 李琴, 刘军, 秦艺玮. 乌司他丁联合连续静-静脉血液透析滤过治疗重症急性胰腺炎的疗效分析[J]. 河北医学, 2017, 23(4): 564-567.
WANG Qi, LU Chengkang, et al. Efficacy Analysis of Ulinastatin Combined with Continuous Venous Hemodialysis in the Treatment of Severe Acute Pancreatitis. 河北医学, 2017, 23(4): 564-567.
[1] 毛建生.乌司他丁治疗老年重症急性胰腺炎并腹内高压的临床效果及对血清学指标的影响[J].中国老年学杂志,2015,35(22):6481~6483. [2] 贾会文,冯延冰,刘向业,等.生长抑素联合乌司他丁对重症急性胰腺炎患者腹内压的影响[J].中国生化药物杂志,2014,34(8):151~153. [3] Jia-KuiSun,Xin-WeiMu,Wei-QinLi,et al.Effects of early enteralnutritio nonimmune function of severea cutepancreatitis patients[J].World Journal of Gastroenterology,2013,(6):917~922. [4] 顾珮瑜,陈敏,马静,等.血必净、乌司他丁联合治疗对老年重症急性胰腺炎患者动脉血乳酸水平和预后影响的临床研究[J].中国医院药学杂志,2012,32(13):1056~1058. [5] Erzhen Chen,Jie Huang,Zhiwei Xu,et al.Clinical features and outcomes of patients with severe acute pancreatitis complicated with gangrenous cholecystitis[J].Hepatobiliary & Pancreatic Diseases International,2013,4(3):317~323. [6] 王晓梅.乌司他丁治疗老年重症急性胰腺炎的疗效及对血清C反应蛋白和细胞间黏附分子-1的影响[J].中国老年学杂志,2014,34(6):1524~1525. [7] 张志兰,徐建婷.连续静-静脉血液滤过对重症急性胰腺炎患者的疗效分析及护理干预[J].中国实用护理杂志,2011,27(20):24~26. [8] 杨春波.连续静-静脉血液滤过在重症急性胰腺炎治疗中的研究进展[J].中国全科医学,2010,13(24):2662~2663. [9] 程斌,龚园其,詹亚琨.短时连续性静-静脉血液透析滤过对重症急性胰腺炎并急性肺损伤的治疗研究[J].中国全科医学,2010,13(24):2664~2666. [10] Fengjiao Yong,Xuanyue Mao,Lihui Deng,et al.Continuousre gionalarterial infusion for the treatment of severe acute pancreatitis:ameta-analysis[J].Hepatobiliary & Pancreatic Diseases International,2015,6(1):10~17.