Abstract：Objective: To investigate the effects of laparoscopic and open cholecystectomy on the immune function and serum inflammatory factors in patients with cholecystolithiasis. Methods: Totally 80 eligible patients were selected and randomly divided into observation group and control group, with 40 patients in each group. The observation group used laparoscopic cholecystectomy, while the control group used open cholecystectomy, and the levels of immune globulin A (IgA), immune globulin M (IgM), immune globulin G (IgG), T lymphocyte subpopulations CD3+, CD4+, and CD8+, hypersensitive C reactive protein (hs-CRP), interleukin-6 (IL-6), and human tumor necrosis factor (TNF-α) and so on in the venous blood were tested before surgery, at 1 d and 5 d after surgery, respectively. Results: At 1 d after surgery, the patients of both groups had significantly decreased serum levels of IgA, IgM, and IgG, CD3+ and CD4+ in peripheral blood, and serum levels of hs-CRP, IL-6, and TNF-α, as well as significantly increased CD8+ level in peripheral blood compared with those before surgery (P<0.05). At 5 d after surgery, the observation group had insignificantly different levels of IgA, IgM, IgG, CD3+, CD4+, CD8+, hs-CRP, IL-6, and TNF-α compared with those before surgery (P>0.05); while the control group had significantly different levels of the above-mentioned factors compared with those before surgery (P<0.05). Before surgery, the two groups had insignificantly different levels of IgA, IgM, IgG, CD3+, CD4+, CD8+, hs-CRP, IL-6, and TNF-α (P>0.05); while at 1 d and 5 d after surgery, the observation group had significantly better levels of the above-mentioned factors than the controlled group (P<0.05). Conclusion: Laparoscopic cholecystectomy and open cholecystectomy have certain trauma, and can affect the immune function. However, the former has the characteristics of less trauma and faster postoperative recovery.
唐钢. 腹腔镜与开腹胆囊切除术治疗胆囊结石对患者免疫功能及血清炎症因子的影响[J]. 河北医学, 2017, 23(2): 221-224.
TANG Gang. Effects of Laparoscopic and Open Cholecystectomy on the Immune Function and Sserum Inflammatory Factors in Patients with Cholecystolithiasis. HeBei Med, 2017, 23(2): 221-224.
2017, Vol. 23 
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