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河北医学  2017, Vol. 23 Issue (2): 212-214    DOI: 10.3969/j.issn.1006-6233.2017.02.011
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新型根管填充介质治疗根管周病的临床疗效及对CypA RANKL水平的影响
陈艳梅, 徐 杰, 易 祥
四川省成都市第二四川省成都市第二医院口腔科,四川 成都 610017
The New Root Canal Filling Medium in Treatment of Root Canal Disease and the Effect on the Level of CypA and RANKL
CHEN Yanmei, XU Jie, YI Xiang
The Second Hospital of Chengdu, Sichuan Chengdu 610017, China
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摘要 目的: 探讨新型根管填充介质治疗根管周病的临床疗效及其对病灶区CypA(亲环蛋白A)、RANKL(核因子-κB受体活化因子配基)水平的影响。方法: 将2013年1月至2016年1月间我院收治的120例牙髓病及根尖周炎患者随机分为观察组和对照组各60例,观察组患者采用牙胶尖及环氧树脂类糊剂进行干预,对照组患者采用使用牙胶尖及氢氧化钙类糊剂进行填充;治疗结束8周后对患者的临床疗效及疼痛情况进行评价;治疗时及治疗后8周时,取患牙牙周组织进行做切片样本,使用免疫组织化学染色法对组织切片中的CypA及RANKL水平进行检查。结果: 观察组患者临床疗效优良率明显高于对照组,差异存统计学意义(P<0.05);经治疗后观察组患者重度疼痛人数比例显著低于对照组(P<0.05),无疼痛人数比例显著高于对照组(P<0.05);经治疗后两组CypA及RANKL水平均显著降低(P<0.05),经治疗后观察组患者病理组织中CypA及RANKL水平明显低于对照组,差异存统计学意义(P<0.05)。结论: 采用新型根管填充介质治疗后可显著提高根管周病患者治疗的临床疗效,并可降低病灶区CypA、RANKL水平,有利于患者康复。
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陈艳梅
徐杰
易祥
关键词 新型根管填充根管周病CypARANKL    
AbstractObjective: To analyze the clinical efficacy of the new root canal filling medium in the treatment of root canal disease and the effect on the level of CypA and RANKL in the lesion area. Methods: 120 cases of pulpitis and periapical periodontitis in our hospital from January 2013 to January 2016 were randomly divided into observation group and control group, with 60 cases in each group, the patients in observation group were treated with gutta percha and epoxy paste intervention, while the patients in control group were treated by using gutta percha and calcium hydroxide paste filling; 8 weeks after the treatment, the clinical efficacy and pain of patients were evaluated; during the treatment and 8 weeks after the treatment, the periodontal tissue was taken to make biopsy samples, the level of CypA and RANKL in tissue sections were examined by using immunohistochemical staining method. Results: The clinical efficacy of patients in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05); after the treatment, the ratio of the number of the patients with severe pain in the observation group was significantly lower than that in the control group (P<0.05), the ratio of the number of the patients with no pain was significantly higher than that in the control group (P<0.05); after the treatment, the level of CypA and RANKL in the two groups were all significantly lower (P<0.05), after the treatment, the level of CypA and RANKL in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05).Conclusion: The new root canal filling medium can significantly improve the clinical efficacy of the treatment of root canal disease, and can reduce the level of CypA and RANKL in the lesion area, which is conducive to the rehabilitation of patients.
Key wordsNew root canal filling    Root canal disease    CypA    RANKL
    
基金资助:四川省卫生厅科研课题,(编号:2013SZ2354)
引用本文:   
陈艳梅, 徐杰, 易祥. 新型根管填充介质治疗根管周病的临床疗效及对CypA RANKL水平的影响[J]. 河北医学, 2017, 23(2): 212-214.
CHEN Yanmei, XU Jie, YI Xiang. The New Root Canal Filling Medium in Treatment of Root Canal Disease and the Effect on the Level of CypA and RANKL. HeBei Med, 2017, 23(2): 212-214.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2017.02.011     或     http://www.hbyxzzs.cn/CN/Y2017/V23/I2/212
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