Abstract：Objective: To study the expression of CK7, CK20, A125 and TTF-1 in liquid based cytology adenocarcinoma cells, and analyze its clinical significance. Methods: 137 cases serous effusion specimens of adenocarcinoma diagnosed in our hospital from February 2015 to March 2016 were selected. Using the liquid based cytology production technology and immunocytochemical staining method, the different tissue derived adenocarcinoma cells CK7, CK20, CA125 and TTF-1 antibodies were observed. Results: The positive rate of CK7 100% in lung adenocarcinoma, most ovarian serous carcinoma express, intestinal adenocarcinoma individual positive; CK20 expression in intestinal adenocarcinoma positive rate was 88.89% (32/36),There's no expression in lung adenocarcinoma; CA125 expression in ovarian serous adenocarcinoma rate was 70.45% (31/44), in lung adenocarcinoma and expression in ovarian serous carcinoma was less; The vera TTF-1 expression in lung adenocarcinoma positive rate was 80.70% (46/57), in ovarian serous carcinoma, and no expression in intestinal adenocarcinoma, differences were statistically significant (all P < 0.05). Poorly differentiated lung adenocarcinoma express the vera.TTF-1 positive rate was significantly lower than the high differentiation, differences were statistically significant (all P < 0.05). Poorly differentiated CA125 expression in ovarian serous carcinoma positive rate was significantly lower than the high differentiation, the difference was statistically significant (P < 0.05). Poorly differentiated CK20 expression in intestinal adenocarcinoma were significantly lower than the high differentiation, the difference was statistically significant (P < 0.05).Conclusion: The expression of CK7, CK20, CA125 and TTF-1 in the liquid based cytology adenocarcinoma cells is beneficial to identify the serous cavity effusion from lung, ovary and intestinal adenocarcinoma.
2017, Vol. 23 
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