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河北医学  2017, Vol. 23 Issue (12): 1970-1973    DOI: 10.3969/j.issn.1006-6233.2017.12.010
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粒细胞集落刺激因子治疗缺血性脑卒中的临床分析
李渝阳1,王琰2
1.重庆市精神卫生中心老年科, 重庆 401147
2.四川省成都市第五人民医院神经内科, 四川 成都 611130
Clinical Analysis of Granulocyte Colony-stimulating Factor in the Treatment of Ischemic Stroke
LI Yuyang, et al
Chongqing Mental Health Center, Chongqing 401147, China
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摘要 目的:探讨粒细胞集落刺激因子(G-CSF)在缺血性脑卒中患者临床治疗中的价值及对患者神经功能的影响。方法:选取120例缺血性脑卒中患者为受试对象,随机数字表法分为研究组和对照组各60例。其中对照组(60例,完成56例,脱落4例),予以常规对症治疗(溶栓、抗凝、改善脑循环、降颅压、吸氧、抗感染、抗脑水肿、脑保护等)措施;研究组(60例,完成54例,脱落6例),在对照组治疗基础上联合重组人粒细胞集落刺激因子注射液[2μg·kg-1·d-1,iH,持续用药5d];均治疗12周后观察疗效。比较两组治疗前后血清神经元特异性烯醇化酶(NSE)、神经肽Y(NPY)、血清核因子-κB(NF-κB)及炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]检测结果变化情况,记录其不良反应发生率,分析治疗前后神经功能[神经功能缺损程度评分(NFDS)]恢复情况差异。结果:治疗5d、12w时,两组血清NSE、NPY、NF-κB检测结果,血清IL-6、TNF-α等炎症因子检测结果及NFDS评分结果均较治疗前显著降低,且研究组<对照组,差异均有统计学意义(P均<0.05)。两组均无严重不良反应发生,轻度食欲减退、恶心、肌肉酸痛、皮疹等不良反应发生率比较均无统计学意义(P>0.05)。结论:G-CSF能有效促进缺血性脑卒中患者脑神经功能恢复,抗炎效果理想,于患者预后恢复有利。
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李渝阳
王琰
关键词 粒细胞集落刺激因子缺血性脑卒中NSENPY    
AbstractObjective: To investigate the value of granulocyte colony-stimulating factor (G-CSF) in the treatment of patients with ischemic stroke and the effect on neurological function. Methods: A total of 120 patients with ischemic stroke were selected as study subjects. By the random number table method, they were divided into study group and control group, 60 cases in each group. The control group (60 cases, 56 cases completed, 4 cases lost to follow up) was treated with conventional symptomatic treatment (thrombolysis, anticoagulation, improving cerebral circulation, lowering intracranial pressure, oxygen inhalation, anti-infection, oxygen inhalation, anti-encephaledema, cerebral protection, etc.); the study group (60 cases, 54 cases completed, 6 cases lost to follow up), was treated combined with recombinant human G-CSF injection [2μg/(kg·d), iH, for 5d], based on the treatment in the control group; curative effect in both groups was observed after 12 weeks of treatment. Changes of serum neuron specific enolase (NSE), neuropeptide Y (NPY), serum nuclear factor kappa B (NF-κB) and inflammatory factors [interleukin - 6 (IL-6), tumor necrosis factor alpha (TNF-α)] before and after treatment were compared between the two groups. The incidence of adverse reactions was recorded, and the differences in neurological function recovery before and after treatment were analyzed. Results: After 5d and 12 weeks of treatment, the test results of serum NSE, NPY, NF-κB, serum IL-6, TNF-a and other inflammatory cytokines and NFDS scores in both groups were significantly lower than those before treatment, and the study group was lower than the control group (P < 0.05). There were no serious adverse reactions in both groups, and there were no significant differences in the incidence rates of mild anorexia, nausea, muscular soreness, rash and other adverse reactions between the two groups (P > 0.05). Conclusion: G-CSF can effectively promote the recovery of neurological function in patients with ischemic stroke, and the anti-inflammation effect is ideal, which is beneficial to the prognosis of patients.
Key wordsGranulocyte colony stimulating factor    Ischemic stroke    NSE    NPY
    
基金资助:四川省卫生计生委科研课题,(编号:1003462)
引用本文:   
李渝阳,王琰. 粒细胞集落刺激因子治疗缺血性脑卒中的临床分析[J]. 河北医学, 2017, 23(12): 1970-1973.
LI Yuyang, et al. Clinical Analysis of Granulocyte Colony-stimulating Factor in the Treatment of Ischemic Stroke. HeBei Med, 2017, 23(12): 1970-1973.
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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2017.12.010     或     http://www.hbyxzzs.cn/CN/Y2017/V23/I12/1970
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