Abstract：Objective: To explore the effects of laparoscopic cholecystectomy (LC) on the efficacy of acute calculouscholecystitis and immune function and postoperative complications. Methods: 88 cases of patients with acute calculous cholecystitis treated in our hospital from March 2015 to February 2017 were selected for the study and divided into two groups: the observation group (n=42, treated with LC surgery) and the control group(n=46, treated with open cholecystectomy/OC) according to the random number table method. The operative time, intraoperative blood loss, postoperative exhaust time, hospital stays, the changes of postoperative serum C-reactive protein (CRP)levels and cortisol levels, postoperative levels of CD3, CD4, CD8 and CD4/CD8, NK cells changes and postoperative complications were compared between the two groups. Results: The operative time was (72.36±12.62) min in the observation group, which was significantly longer than that of the control group (P<0.05). The intraoperative blood loss amount was (173.63±22.65) ml in the observation group, which was significantly less than that in the control group (P<0.05). The postoperative exhaust time and hospital stays were (21.74±7.96) h and (6.35±2.01) d, which were significantly shorter than those of the control group (P<0.05). The levels of serum CRP and cortisol were (4.36±0.25) mg/dl and (257.83±10.74) ng/ml respectively in the observation group, which were significantly lower than those in the control group (P<0.05). The percentage of CD3, CD4, CD8, CD4/CD8 and NK cells were (64.39±5.37)%, (35.74±3.81)%, (23.65±3.17)%, (1.51±0.08) and (16.46±2.85) %in the observation group, which were significantly higher than those in the control group (P<0.05). The total incidence rate of postoperative complications was 4.76% in the observation group, which was significantly lower than that in the control group with19.57% (P<0.05). Conclusion: LC can have a significant effect, and can effectively reduce the patient's postoperative stress response and immune function inhibition, and reduce the incidence rate of complications in the treatment of acute calculous cholecystitis.
章密密, 刘先武, 胡兴明, 王建. 腹腔镜胆囊切除术治疗急性结石性胆囊炎的疗效及对免疫功能术后并发症的影响[J]. 河北医学, 2017, 23(11): 1810-1813.
ZHANG Mimi, LIU Xianwu, HU Xingming, et al. Effects of Laparoscopic Cholecystectomy on Efficacy of Acute Calculous Cholecystitis and Immune Function and Postoperative Complications. HeBei Med, 2017, 23(11): 1810-1813.
2017, Vol. 23 
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