Abstract：Objective: To analyze the risk factors of penetrating demyelinating syndrome after severe traumatic brain injury, and to provide reference for clinical prevention and treatment. Methods: Retrospective analysis of clinical data from March 2011 to March 2016 in our hospital of 450 cases of severe craniocerebral trauma patients, according to whether the occurrence of osmotic demyelination syndrome (ODS) were divided into ODS group and non ODS group, compared two groups of patients with gender, age, admission damage degree (GCS score), associated injuries, cerebral contusion and the brain, skull fracture, hypotension, traumatic subarachnoid hemorrhage, hematoma, difference of mannitol dosage index. Results: 450 cases of patients with severe traumatic brain injury in the occurrence of osmotic demyelination syndrome in 11 cases, the incidence rate of 2.44%; Single factor analysis showed that the age of the ODS group was significantly higher than the control group, severe injury, injury, hypotension, cerebral hernia, brain contusion, hematoma was significantly higher than non ODS group (t=9.584, χ2=4.877~9.584, P<0.05); Multi Logistic regression analysis showed that age, GCS score (3-8), cerebral contusion, hematoma clearance, hypotension for severe brain tallage risk factors after osmotic demyelination syndrome (β=0.032~0.754, S.E= 0.007~0.302, Wald = 5.324~28.302, P<0.05). Conclusion: The osmotic demyelination syndrome with age and severity of injury, injury type and other factors related to severe traumatic brain injury, we should strengthen the prevention of risk factors, reduce the incidence of osmotic demyelination syndrome.
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2017, Vol. 23 
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