肾病综合征患者外周血T细胞亚群及血清脂联素水平与患者激素治疗效果的关系

doi:10.3969/j.issn.1006-6233.2017.10.018

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摘要 目的: 探讨原发性肾病综合征患者外周血中T细胞亚群(Treg)及血清脂联素(APN)水平与患者激素治疗效果的关系。方法: 选择2014年5月至2016年5月期间在我院诊断为原发性肾病综合征的80例患者作为研究对象,并以35例健康志愿者作为对照组,所有患者均检测Treg及APN水平,所有患者均采用激素标准方案治疗,探讨血清中T细胞亚群及血清中脂联合素水平与患者激素治疗效果及预后的关系。结果: 观察组外周血中Treg细胞百分比为4.25±1.32,低于对照组,APN、T辅助细胞17(Th17)、Th17/Treg细胞含量分别为33.6±12.5、1.63±0.26、0.51±0.07,高于对照组患者,差异具有统计学意义(P<0.05);以Treg细胞百分比中位数分为低水平组和高水平组,结果低水平组患者38例、高水平组患者42例,低和高水平组患者激素治疗敏感分别为19例(50%)和26例(61.90%);以血清中APN中位数分为低水平组和高水平组,结果低水平组患者39例,高水平组患者41例,低和高水平组患者激素治疗敏感分别为19例(48.7%)和26例(63.41%),这两组之间比较差异无统计学意义(P>0.05)。结论: 肾病综合征患者血清中Treg细胞含量和脂联素水平与激素治疗效果密切相关。

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	朱磊
	解德琼
	张臣丽
	吴娅琳

关键词 ：肾病综合征, Treg, 脂联素, 激素, 效果

Abstract：Objective: To investigate the relationship between peripheral blood T lymphocyte subsets(Treg), serum adiponectin (APN) levels and the effect of hormone therapy in patients with nephrotic syndrome. Methods: 80 cases of primary nephrotic syndrome patients were selected during May 2014 to May 2016 in our hospital.35 healthy volunteers as control group, all patients were detected in the serum adiponectin level in patients with T cell subsets and serum in all patients using standard hormone treatment, serum T cell subsets and serum lipid in the association between hormone levels and treatment effect and prognosis of patients with hormone. Results: The levels of peripheral blood Treg cells in patients of the observation group was 4.25±1.32,which significantly lower than that in patients of the control group; The levels of APN, T helper cell 17 (Th17) and the ratio of Th17/Treg cells were 33.6±12.5 mg/L, 1.63± 0.26, 0.51 ± 0.07, which significantly higher than that in the control group (P<0.05). Patients were divided into low and high levels of hormone-sensitive therapy based on the numbers of Treg cells, and the results showed 38 cases of patients in the low-level group and 42 cases in high level group. Of them, 19 cases (50%) and 26 cases (61.90%) in the low-level and high-level groups respectively, were sensitive to hormone therapy. Patients were divided into low-level and high-level groups based on the median of serum APN and the results showed 39 and 41 cases of patients that sensitive to hormone therapy. Of them, 19 cases (48.70%) and 26 cases (63.41%) in the low-level and high-level groups respectively, were sensitive to hormone therapy. The difference was not statistically significant, P>0.05. Conclusion: The number of Treg cells and serum adiponectin levels were closely related to the effect of hormone therapy.

Key words： Nephrotic syndrome Treg Adiponectin Hormone Effect

基金资助:四川省卫生厅基金资助项目,(编号:SC081920)

引用本文:

朱磊, 解德琼, 张臣丽, 吴娅琳. 肾病综合征患者外周血T细胞亚群及血清脂联素水平与患者激素治疗效果的关系[J]. 河北医学, 2017, 23(10): 1646-1648.
ZHU Lei, XIE Deqiong, ZHANG Chengli, et al. The Relationship between Peripheral Blood T Lymphocyte Subsets| Serum Adiponectin Levels and the Effect of Hormone Therapy| in Patients with Nephrotic Syndrome. 河北医学, 2017, 23(10): 1646-1648.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2017.10.018 或 http://www.hbyxzzs.cn/CN/Y2017/V23/I10/1646

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