Abstract:Objective: To study the C - reactive protein (CRP), serum prealbumin (PA), serum calcitonin original joint detection (PCI) in the diagnosis of infectious disease clinical value.Selection Methods: our hospital between 2015 and 2016 of 108 patients with infectious diseases were divided into viral infection group of 43 patients with bacterial infection group 65 examples, selecting the healthy physical examination were 50 cases for the same period as the healthy control group.Results: CRP, PCI in patients with bacterial infection group was obviously higher than that of other two groups (P < 0.05), PA significantly lower than the other two groups (P < 0.05), the level of CRP, PCI virus infection group was obviously higher than that of control group (P < 0.05), the virus infection group and control group in the PA has no obvious difference (P > 0.05).Respectively by PCT > 5 ng/ml, CRP > 50 mg/L, PA < 180 mg/L for the standard statistical positive rate, positive rate of patients with bacterial infection group were significantly increased (P < 0.05).Conclusion: the serum PCT and CRP and PA indexes can be used for clinical diagnosis of infectious disease, can be a distinction between infection of pathogenic bacteria, but joint detection methods with higher accuracy.