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河北医学  2017, Vol. 23 Issue (1): 35-37    DOI: 10.3969/j.issn.1006-6233.2017.01.012
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血清同型半胱氨酸与癫痫患者认知功能损害的关系探讨
李娇健, 董岩, 郎朗, 刘海兵
辽宁省阜新矿业集团总医院神经内科, 辽宁 阜新 123000
The Relationship between Serum Homocysteine and Cognitive Impairment in Patients with Epilepsy
LI Jiaojian, DONG Yan, LANG Lang, et al
Fuxin Mining Group General Hospital of Liaoning, Liaoning Fuxin 123000, China
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摘要 目的: 探讨血清同型半胱氨酸(Hcy)与癫痫患者认知功能损害(MCI)的相关性。方法: 将120例癫痫患者按照认知功能是否存在损害分为MCI组(51例)和非MCI组(69例),对两组患者Hcy、S-腺苷甲硫氨酸(SAM)、S-腺苷同型半胱氨酸(SAH)水平进行测定,并探讨Hcy水平与简易精神状态评价量表(MMSE)评分的相关性。结果: MCI组患者血清Hcy、SAH水平均明显高于非MCI组(P<0.05),MCI组患者血清SAM水平明显低于非MCI组(P<0.05),当血清Hcy水平<15.0μmoL/L时,患者MMSE评分与血清Hcy浓度无明显相关性(r=-0.19,P>0.05);当血清Hcy水平≥15.0μmoL/L时,患者MMSE评分与血清Hcy浓度呈负相关性(P<0.05)。结论: 血清Hcy与癫痫患者MCI有一定相关性,临床可据此进行辅助诊断。
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李娇健
董岩
郎朗
刘海兵
关键词 血清同型半胱氨酸癫 痫认知功能损害    
AbstractObjective: To study the relationship between serum homocysteine (Hcy) and cognitive impairment (MCI) in patients with epilepsy. methods: 120 patients with epilepsy were divided into MCI group (n = 51) and non MCI group according to the impairment of cognitive function (n = 69). The Hcy, S-adenosine methionine (SAM), S-adenosine homocysteine (SAH) levels of were determined, and the Hcy levels and simple mental state assessment scale (MMSE) score were detected. Results: The serum level of Hcy and SAH of patients in MCI group were significantly higher than that in MCI group (P < 0.05); SAM serum level in patients with MCI group was obviously lower than the MCI group (P < 0.05); while serum Hcy levels < 15.0 umoL/L, MMSE score and serum Hcy concentration in patients had no significant correlation (r = 0.19, P > 0.19); When serum Hcy levels acuity 15.0 mu moL/L, MMSE score and serum Hcy concentration had negative correlation (P < 0.05). Conclusion: There are some correlations between serum Hcy and epilepsy patients with MCI. Clinical diagnosis can be carried out accordingly it.
Key wordsThe serum homocysteine    Epilepsy    Cognitive impairment
    
基金资助:辽宁省科技厅计划项目,(编号:2004225003-8)
引用本文:   
李娇健, 董岩, 郎朗, 刘海兵. 血清同型半胱氨酸与癫痫患者认知功能损害的关系探讨[J]. 河北医学, 2017, 23(1): 35-37.
LI Jiaojian, DONG Yan, LANG Lang, et al. The Relationship between Serum Homocysteine and Cognitive Impairment in Patients with Epilepsy. HeBei Med, 2017, 23(1): 35-37.
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