Abstract：Objective: To study the relationship between serum homocysteine (Hcy) and cognitive impairment (MCI) in patients with epilepsy. methods: 120 patients with epilepsy were divided into MCI group (n = 51) and non MCI group according to the impairment of cognitive function (n = 69). The Hcy, S-adenosine methionine (SAM), S-adenosine homocysteine (SAH) levels of were determined, and the Hcy levels and simple mental state assessment scale (MMSE) score were detected. Results: The serum level of Hcy and SAH of patients in MCI group were significantly higher than that in MCI group (P < 0.05); SAM serum level in patients with MCI group was obviously lower than the MCI group (P < 0.05); while serum Hcy levels < 15.0 umoL/L, MMSE score and serum Hcy concentration in patients had no significant correlation (r = 0.19, P > 0.19); When serum Hcy levels acuity 15.0 mu moL/L, MMSE score and serum Hcy concentration had negative correlation (P < 0.05). Conclusion: There are some correlations between serum Hcy and epilepsy patients with MCI. Clinical diagnosis can be carried out accordingly it.
李娇健, 董岩, 郎朗, 刘海兵. 血清同型半胱氨酸与癫痫患者认知功能损害的关系探讨[J]. 河北医学, 2017, 23(1): 35-37.
LI Jiaojian, DONG Yan, LANG Lang, et al. The Relationship between Serum Homocysteine and Cognitive Impairment in Patients with Epilepsy. HeBei Med, 2017, 23(1): 35-37.
[1] 郎晓玲.癫痫患者情感障碍和认知功能障碍的关系及其影响因素的研究[J].中国保健营养,2014,37(4):37~41. [2] 宋晓宇.ApoE基因多态性与颞叶癫痫及癫痫后认知功能障碍的相关性研究[D].吉林大学,2016. [3] 周东,汪颖,吴逊.国际抗癫痫联盟委员会关于癫痫发作和癫痫诊断方案的建议[J].中华神经科杂志,2003,36(4):302~307. [4] Protet F. Ousset P J. Visser P J,et al. Mild cognitive impairment(MCI) in medical practice: a cretical review of the and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimers Disease[J].Neurol Neurosurg Psychiatry, 2006, 77(6):714~718. [5] 周华东,主编.神经系统疾病诊治流程规范[M].北京:军事医学科学出版社,2009.514~518. [6] 薛涛,郭改艳,王娟娟.原发性癫痫患者认知功能障碍的临床特征及相关因素分析[J].中国实用神经疾病杂志,2015,23(24):514~518.
2017, Vol. 23 
冀公网安备13080202000786号