血清同型半胱氨酸与癫痫患者认知功能损害的关系探讨

doi:10.3969/j.issn.1006-6233.2017.01.012

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摘要 目的: 探讨血清同型半胱氨酸(Hcy)与癫痫患者认知功能损害(MCI)的相关性。方法: 将120例癫痫患者按照认知功能是否存在损害分为MCI组(51例)和非MCI组(69例),对两组患者Hcy、S-腺苷甲硫氨酸(SAM)、S-腺苷同型半胱氨酸(SAH)水平进行测定,并探讨Hcy水平与简易精神状态评价量表(MMSE)评分的相关性。结果: MCI组患者血清Hcy、SAH水平均明显高于非MCI组(P<0.05),MCI组患者血清SAM水平明显低于非MCI组(P<0.05),当血清Hcy水平<15.0μmoL/L时,患者MMSE评分与血清Hcy浓度无明显相关性(r=-0.19,P>0.05);当血清Hcy水平≥15.0μmoL/L时,患者MMSE评分与血清Hcy浓度呈负相关性(P<0.05)。结论: 血清Hcy与癫痫患者MCI有一定相关性,临床可据此进行辅助诊断。

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	李娇健
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	郎朗
	刘海兵

关键词 ：血清同型半胱氨酸, 癫痫, 认知功能损害

Abstract：Objective: To study the relationship between serum homocysteine (Hcy) and cognitive impairment (MCI) in patients with epilepsy. methods: 120 patients with epilepsy were divided into MCI group (n = 51) and non MCI group according to the impairment of cognitive function (n = 69). The Hcy, S-adenosine methionine (SAM), S-adenosine homocysteine (SAH) levels of were determined, and the Hcy levels and simple mental state assessment scale (MMSE) score were detected. Results: The serum level of Hcy and SAH of patients in MCI group were significantly higher than that in MCI group (P < 0.05); SAM serum level in patients with MCI group was obviously lower than the MCI group (P < 0.05); while serum Hcy levels < 15.0 umoL/L, MMSE score and serum Hcy concentration in patients had no significant correlation (r = 0.19, P > 0.19); When serum Hcy levels acuity 15.0 mu moL/L, MMSE score and serum Hcy concentration had negative correlation (P < 0.05). Conclusion: There are some correlations between serum Hcy and epilepsy patients with MCI. Clinical diagnosis can be carried out accordingly it.

Key words： The serum homocysteine Epilepsy Cognitive impairment

基金资助:辽宁省科技厅计划项目,(编号:2004225003-8)

引用本文:

李娇健, 董岩, 郎朗, 刘海兵. 血清同型半胱氨酸与癫痫患者认知功能损害的关系探讨[J]. 河北医学, 2017, 23(1): 35-37.
LI Jiaojian, DONG Yan, LANG Lang, et al. The Relationship between Serum Homocysteine and Cognitive Impairment in Patients with Epilepsy. HeBei Med, 2017, 23(1): 35-37.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2017.01.012 或 http://www.hbyxzzs.cn/CN/Y2017/V23/I1/35