Abstract：Objective: To study the relationship between APACHEII score and serum ET, IGF-, CNP levels and prognosis in patients with traumatic brain injury. methods: 80 cases of craniocerebral trauma patients admitted in our hospital from Oct. 2011 to Dec. 2015 were selected and divided into mild group (GCS 13~15 points), moderate group (GCS 9~12) and severe group (GCS 3-8 minutes) according to Glasgow Coma Scale (GCS). Endothelin (ET), insulin like growth factor II (IGF-II) and C-type natriuretic peptide (CNP) were collected at admission and the content of serum was measured. General condition was evaluated by Acute Physiology and Chronic Health Evaluation II (APACHE II); 6 months after trauma, prognosis was evaluated by Glasgow Outcome Score (GOS). Results: Patients with different severity of craniocerebral trauma of APACHE II score has significant difference (P < 0.05); moderate group and the severe group patients with APACHE II score was lower than that of the mild group and severe group patients with APACHE II score lower than the medium group. Different severity in patients with traumatic brain injury serum ET, IGF-II and CNP levels have significant difference (P < 0.05); moderate group and the severe group patients serum ET levels higher than mild group, IGF-II, CNP levels lower than mild group, severe group patients serum ET level is higher than the medium group, IGF-II, CNP below medium group. A good prognosis in patients with traumatic brain injury, serum levels of ET was significantly lower than that of poor prognosis in patients with traumatic brain injury, IGF-II, CNP was significantly higher than that of poor prognosis in patients with traumatic brain injury, APACHE II score was significantly higher than that of poor prognosis in patients with traumatic brain injury. Conclusion: The serum ET, IGF- and CNP score is correlated with the severity of brain injury, which could be used for the evaluation of short term and long term prognosis.
王安帮, 宋波. 颅脑外伤患者APACHEII评分与血清中ET IGF-Ⅱ CNP水平及患者预后的关系[J]. 河北医学, 2017, 23(1): 32-34.
WANG Anbang, et al. Relationship between APACHEII Score and Serum ET IGF-Ⅱ CNP Levels and Prognosis in Patients with Traumatic Brain Injury. HeBei Med, 2017, 23(1): 32-34.
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2017, Vol. 23 
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