Abstract：Objective: To investigate the effect of dexmedetomine (DEX) on close-loop muscle relaxant injection system using cisatracurium (CIS) in laparoscopic cholecystectomy (LC). Methoyds: 60 patients undergoing LC under general anesthesia with tolal intravenous anesthesia were randomly divided into three groups: group A, normal saline (NS)+3ED95CIS; group B, DEX+3ED95CIS; group C, DEX+4ED95CIS 20 case in each group. In group B and C, a bolus close of 1.0μg/kg DEX was infused before 15 minutes of induction, followed by continous infusion of 0.5μg/kg/h untill 20 min before the operation ended. Normal saline was infused in the same way in group A. The onset time, intubation condition, the first-time to add medicine, clinic effect time, the time from stopped close-loop muscle relaxant to recovery of TOF to 0.2,0.5,0.7,0.9, and recovery index (RI) of CIS. Results: There were no statistical significant on onset time, intubation condition, the first time to add medicine, clinical cluration, the time from stopped close-loop muscle relaxant to recovery of TOF to 0.2,0.5,0.7,0.9 and RI of CIS in groupAand group B. Comparison between group C and group A, onset time of group C was shorter than in group A (P<0.05), and first add medicine time longer than group A (P<0.05). Comparison between group B and group C, onset time of group C shorter than group B, first add medicine time longer than group B (P<0.05). The intubation condition in group C was better than in group B (P<0.05). Conclusion: DEX can not affect metablism and effect of CIS with closed-loop muscle relaxant injection, but it can improve the condition of intubation. Use DEX conbined with CIS was safe to the patient.
[1] 魏栋,等.顺式阿曲库铵用于老年患者肌松效应的临床观察[J].当代医学,2012,8:137~138. [2] Eieveid DJ,ProostJH,WierdaJM.Evaiuation ofaciosed-ioop musciereiaxation controisystem[J].Anesth Anaig,2005,101(3):758~764. [3] Herweling A ,Latorre F,Herwig A ,et al .The hemodynamic effects of ephedrine on the onset time of rocuronium in pigs[J].Anesth Analg, 2004,99(6):1703~1707. [4] Musgrave I F,Krautwurst D ,Schultz G .Imidazoline binding sites and signal transduction pathways[J].Clin Exp Pharmacol physiol, 1996, 23(10-11):990~994.
2017, Vol. 23 
冀公网安备13080202000677号