Abstract：Objective: To analyze the correlation between soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), Ghrelin/Obestatin levels and postoperative pulmonary infection in gastric cancer, and evaluate their predictive value for postoperative pulmonary infection in gastric cancer. Methods: A total of 148 gastric cancer patients who underwent surgery at our hospital between June 2021 and June 2024 were enrolled. The serum levels of sTREM-1 and Ghrelin/Obestatin were measured on the day after surgery. The patients were followed up for 1 month postoperatively and divided into an infection group (n=65) and a non-infection group (n=83) based on the occurrence of pulmonary infection. The predictive value of sTREM-1 and Ghrelin/Obestatin levels for postoperative pulmonary infection was evaluated using receiver operating characteristic (ROC) curves. Results: The sTREM-1 level in the infection group was higher than that in the non-infection group, while the Ghrelin/Obestatin level in the infection group was lower than that in the non-infection group (P<0.05). The ROC curve showed that the area under the curve (AUC) for sTREM-1 and Ghrelin/Obestatin levels in predicting postoperative pulmonary infection in gastric cancer was 0.773 and 0.761, respectively, with sensitivity of 64.62% and 66.15%, and specificity of 84.34% and 77.11%, respectively. The AUC for combined prediction was 0.963, with sensitivity of 92.31% and specificity of 90.36%. The combined prediction performance was superior to that of individual markers (P<0.05). Conclusion: sTREM-1 and Ghrelin/Obestatin levels are closely associated with postoperative pulmonary infection in gastric cancer. Early measurement of these levels postoperatively may provide valuable predictive information for postoperative pulmonary infection in gastric cancer.
刘申芳, 穆晓艳, 胥晓萍, 许彬. sTREM-1 Ghrelin/Obestatin与胃癌术后肺部感染相关性及预测价值[J]. 河北医学, 2025, 31(2): 311-315.
LIU Shenfang, MU Xiaoyan, XU Xiaoping, et al. Correlation and Predictive Value of sTREM-1 and Ghrelin/Obestatin with Postoperative Pulmonary Infection in Gastric Cancer. HeBei Med, 2025, 31(2): 311-315.
[1] 叶泉忠,陈大军,林小花.血清PG-Ⅰ、PG-Ⅱ、CA242检测在胃癌早期诊断及术前分期中的应用[J].现代实用医学,2022,34(11):1444-1446,1454. [2] Zheng F.Pathogenic characteristics of pulmonary infection in hospitalized patients with chronic heart failure and diagnostic value of sTREM-1,sCD163,and sTWEAK[J].Pak Med Sci,2022,38(3):536-541. [3] Tang D,Ge H,Tan Z,et al.The factors for the occurrence of pulmonary infection after gastrointestinal surgery and the construction of a predictive model using sTREM-1 and TIM-4: a retrospective study[J].Ann Ital Chir,2024,95(3):299-307. [4] Kzlrmak D,Bozkurt B,Karamanl H.Relationship between ghrelin and obestatin levels and ghrelin/obestatin ratio in patients with asthma[J].Tuberk Toraks,2020,68(1):9-16. [5] 国家卫生健康委员会.胃癌诊疗规范(2018年版)[J].中华消化病与影像杂志(电子版),2019,9(3):118-144. [6] 王林俊,夏义文,李铮,等.胃癌手术质量控制数据的公布推动胃癌手术水平的提高:基于2020-2022年江苏省胃癌质量控制数据分析[J].肿瘤,2024,44(2):136-145. [7] 谭婷,陈碧涛,朱鹏程,等.胃癌术后肺部感染危险因素及血清PCT、CRP水平的预测价值分析[J].中国病原生物学杂志,2023,18(8):952-956. [8] 田浩印,李志娜,李静,等.术前肺功能、术后sTREM-1、小野寺指数诊断NSCLC患者术后肺部感染的价值[J].标记免疫分析与临床,2023,30(2):298-303. [9] Uygur FA,Dii E,Peksz R,et al.Diagnostic value of serum levels of galanin and obestatin in patients with gastric cancer[J].Rev Assoc Med Bras (1992),2022,68(7):888-892. [10] 李永杰,闫其星,周源,等.sTREM-1、HMGB1和内毒素对胸腔镜肺癌根治术后肺部感染的预测价值[J].临床和实验医学杂志,2023,22(10):1065-1069. [11] 邓波,韩琦,朱必胜,等.血清PCT、TIM-4、sTREM-1联合检测对胃肠手术后肺部感染的预测价值[J].局解手术学杂志,2023,32(6):540-543.
2025, Vol. 31 
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