Abstract：Objective: To analyze the changes in serum inflammatory factors in patients with xerophthalmia after modified Parks incision strabismus surgery and to investigate their association with ocular surface function. Methods: A total of 122 patients with strabismus who underwent modified Parks incision surgery at our hospital from March 2021 to March 2024 were included in this study. The changes in inflammatory factors among patients with xerophthalmia after surgery were observed, and the relationship between these changes and ocular surface function was analyzed. Results: The incidence rate of xerophthalmia after modified Parks incision strabismus surgery was 21.31% (26/122). The serum levels of IL-6, MMP-2, TNF-α, and TLR4 in patients with xerophthalmia were significantly higher than those in patients without xerophthalmia (P<0.05). There was a statistically significant difference in OSDI scores between patients with and without xerophthalmia (P<0.05). Pearson correlation analysis indicated that IL-6, MMP-2, TNF-α, and TLR4 were positively correlated with the degree of ocular surface dysfunction, with statistically significant correlations (r=0.482, 0.510, 0.351, 0.333, P<0.05). Linear regression analysis showed that IL-6, MMP-2, TNF-α, and TLR4 were risk factors affecting ocular surface function (P<0.05). ROC curve analysis revealed that the AUCs of serum IL-6, MMP-2, TNF-α, and TLR4 in evaluating ocular surface dysfunction were 0.668, 0.752, 0.743, and 0.766, respectively. The combined AUC of IL-6+MMP-2+TNF-α+TLR4 was 0.873, with a sensitivity and specificity of 0.769 and 0.854, respectively, under the maximum Youden index. Conclusion: The serum levels of IL-6, MMP-2, TNF-α, and TLR4 in patients with xerophthalmia after modified Parks incision strabismus surgery are abnormally increased and are related to the degree of ocular surface dysfunction. These levels have a high evaluative value for ocular surface dysfunction.
程靖倩, 王爽, 覃冬. 改良Parks切口斜视手术后干眼症患者炎症因子与眼表功能的关系研究[J]. 河北医学, 2025, 31(1): 127-132.
CHENG Jingqian, WANG Shuang, QIN Dong. Relationship Between Inflammatory Factors and Ocular Surface Function in Patients with Xerophthalmia After Modified Parks Incision Strabismus Surgery. HeBei Med, 2025, 31(1): 127-132.
[1] Papalia GF,Mangano G,Diaz Balzani LA,et al.Strabismus and postural control:a systematic review[J].Musculoskelet Surg,2022,106(4):345-356. [2] Sakallioglu AK,Garip R.Corneal dellen development after strabismus surgery[J].Strabismus,2021,29(4):221-227. [3] Sneidrova J,Novotny T.Binocular function in adults before and after strabismus surgery[J].Cesk Slov Oftalmol,2023,79(6):296-302. [4] 陈星怡,罗燕,梁明,等.国产玻璃酸钠联合聚乙二醇滴眼液治疗斜视术后干眼症的效果观察[J].河北医学,2023,29(3):511-516. [5] 狄宇,李莹.干眼炎症反应机制及抗炎治疗的研究进展[J].山东大学耳鼻喉眼学报,2022,36(2):144-150. [6] Wagner RS.Minimizing complications during strabismus surgery[J].Pediatr Ophthalmol Strabismus,2022,59(4):208. [7] Gong X,Yao H,Wu J.Sodium hyaluronate combined with rhEGF contributes to alleviate clinical symptoms and Inflammation in patients with Xerophthalmia after cataract surgery[J].BMC Ophthalmol,2022,22(1):58. [8] 高轶,魏超群,弥禹,等.干眼的免疫机制研究进展[J].国际眼科杂志,2022,22(8):1313-1317. [9] 雄飞,张跃红,张柳,等.术前双氯芬酸钠滴眼液联合术后妥布霉素地塞米松滴眼液对家兔白内障术后炎症反应的影响[J].中国药师,2021,24(1):64-69. [10] 傅张倚天,万咪咪,赖思华,等.电针通过调控TLR4介导的炎症信号通路改善糖尿病干眼大鼠角膜炎症的机制研究[J].眼科新进展,2024,44(1):24-29.
2025, Vol. 31 
冀公网安备13080202000677号