血尿酸 SHG比值 TyG指数与AMI患者MACE发生的相关性分析

doi:10.3969/j.issn.1006-6233.2024.12.030

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摘要 目的: 分析血尿酸、应激性高血糖(SHG)比值、甘油三酯-葡萄糖(TyG)指数与急性心肌梗塞(AMI)患者心血管不良事件(MACE)发生的相关性。方法: 回顾性分析2019年11月至2023年11月宣城市人民医院收治234例AMI患者的临床资料,根据患者MACE发生情况分为AMI组(未发生MACE患者,n=182)和MACE组(发生MACE患者,n=52),比较两组患者临床资料及实验室检测指标,分析影响AMI发生MACE的危险因素,采用ROC曲线评估血尿酸、SHG比值、TyG指数对AMI患者MACE发生的预测效能。结果: 梗塞至再灌注时间、血尿酸、SHG比值、TyG指数、Scr、cTnT、LVEF均是影响AMI患者MACE发生的危险因素(P<0.05)。血尿酸、SHG比值、TyG指数水平曲线均对AMI患者MACE发生有一定预测价值(AUC>0.5),其敏感度分别为86.54%、76.92%、67.31%,特异度分别为45.60%、67.58%、67.58%,cut-off值分别为337.31μmoL/L、1.16、4.21。结论: 血尿酸、SHG比值、TyG指数与AMI患者MACE发生具有一定相关性,其水平越高,患者发生MACE风险越大,临床可将血尿酸、SHG比值、TyG指数作为AMI患者术后发生MACE的预测指标,以便早期采取针对性预防措施,尽可能改善患者预后。

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关键词 ：急性心肌梗塞, 血尿酸, 应激性高血糖比值, 甘油三酯-葡萄糖指数, 心血管不良事件, 相关性

Abstract：Objective: To analyze the correlation between serum uric acid, stress hyperglycemia (SHG) ratio, triglyceride-glucose (TyG) index, and occurrence of major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).Methods: The clinical data of 234 patients with AMI in Xuancheng People' s Hospital were retrospectively analyzed from November 2019 to November 2023. According to the occurrence of MACE, the patients were divided into AMI group (patients without MACE, n=182) and MACE group (patients with MACE, n=52). The clinical data and laboratory detection indicators were compared between groups of patients, and the risk factors for MACE in AMI were analyzed. ROC curve was used to evaluate the predictive efficiency of serum uric acid, SHG ratio and TyG index on MACE in AMI patients.Results: Time from infarction to reperfusion, serum uric acid, SHG ratio, TyG index, Scr, cTnT and LVEF were all risk factors for MACE in AMI patients (P<0.05). The curves of serum uric acid, SHG ratio and TyG index all had certain predictive value on MACE in AMI patients (AUC>0.5), and their sensitivities were 86.54%, 76.92% and 67.31%, the specificities were 45.60%, 67.58% and 67.58%, and the cut-off values were 337.31 μmol/L, 1.16 and 4.21 respectively.Conclusion: Serum uric acid, SHG ratio, and TyG index have a certain correlation with the occurrence of MACE in AMI patients. The higher the above indicators, the greater the risk of MACE in patients. Clinically, serum uric acid, SHG ratio and TyG index can be used as predictive indicators of postoperative MACE in AMI patients in order to take early targeted preventive measures and improve the prognosis of patients as much as possible.

Key words： Acute myocardial infarction Serum uric acid Stress hyperglycemia ratio Triglyceride-glucose index Major adverse cardiovascular events Correlation

基金资助:山西省应用基础研究项目,(编号:201801D221273);2023年度宣城市卫生健康科研项目,(编号:XCWJ2023033);皖南医学院教学医院科研专项计划,(编号:WK2023JXYY147)

通讯作者: 方存明

引用本文:

伍超, 胡学俊, 刘冰, 龚天奎, 方存明, 逯朝阳. 血尿酸 SHG比值 TyG指数与AMI患者MACE发生的相关性分析[J]. 河北医学, 2024, 30(12): 2102-2106.
WU Chao, HU Xuejun, LIU Bing, et al. Correlation of Serum Uric Acid SHG Ratio and TyG Index with Occurrence of MACE in Patients with AMI. HeBei Med, 2024, 30(12): 2102-2106.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2024.12.030 或 http://www.hbyxzzs.cn/CN/Y2024/V30/I12/2102

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